Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington's disease: a quantitative Golgi study

• Published in: Neurology Vol. 43; no. 10; p. 2088
• Main Authors: Sotrel, A, Williams, R S, Kaufmann, W E, Myers, R H
• Format: Journal Article
• Language: English
• Published: United States 01.10.1993
• Subjects: Adult; Aged; Autopsy; Cerebral Cortex - pathology; Dendrites - ultrastructure; Female; Golgi Apparatus - ultrastructure; Humans; Huntington Disease - pathology; Male; Middle Aged; Nerve Degeneration; Neuronal Plasticity; Neurons - pathology; Pyramidal Tracts - pathology

Aided by a computer microscope, the Eutectic Neuron Tracing System, we performed a quantitative analysis of 59 rapid Golgi-impregnated pyramidal neurons from the third and fifth prefrontal cortical layers (P III and P V neurons) in tissue sections obtained from seven autopsied Huntington's dise...