Discovery of serum metabolites for diagnosis of progression of mild cognitive impairment to Alzheimer's disease using an optimized metabolomics method

• Published in: RSC advances Vol. 6; no. 5; pp. 3586 - 3591
• Main Authors: Liang, Qun, Liu, Han, Zhang, Tianyu, Jiang, Yan, Xing, Haitao, Zhang, Ai-hua
• Format: Journal Article
• Language: English
• Published: 01.01.2016
• Subjects: Alzheimer disease; Biomarkers; blood serum; cognitive disorders; Diagnosis; Impairment; Mathematical models; Metabolites; metabolomics; Monitoring; patients; prediction; principal component analysis; Progressions; Serums

Mild cognitive impairment (MCI) is considered to represent early AD. Currently, there is a great need for sensitive tools to monitor the progression of MCI to AD. In this work, a nontargeted metabolomics approach was developed to examine metabolic differences in serum samples from the MCI subjects a...