The overexpression of miR-146a in hippocampal microglia via IRAK1/TRAF6/NF-κB pathway improves cognitive function in diabetic mice

• Published in: Experimental neurology Vol. 391; p. 115291
• Main Authors: Zhang, Jingyu, Lin, Xiaoyun, Huang, Qing, Fu, Zhang, Huang, Yihuan, Chen, Zhiqing, Li, Ningning, Lin, Xiahong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2025
• Subjects: Animals; Cognition - physiology; Cognitive dysfunction; Cognitive Dysfunction - metabolism; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - psychology; Diabetic encephalopathy; Hippocampus - metabolism; Interleukin-1 Receptor-Associated Kinases - biosynthesis; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-1 Receptor-Associated Kinases - metabolism; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; miR-146a; Neuroimmune; NF-kappa B - biosynthesis; NF-kappa B - metabolism; Signal Transduction - physiology; TNF Receptor-Associated Factor 6 - biosynthesis; TNF Receptor-Associated Factor 6 - metabolism; miR-146a; Diabetic encephalopathy; Neuroimmune; Cognitive dysfunction; Microglia

Diabetic encephalopathy (DEP), a central nervous system complication of diabetes, is primarily characterized by cognitive dysfunction. Despite its high prevalence and significant risks, the pathogenesis remains poorly understood. This study investigates the effects and mechanisms of miR-146a on cogn...