The overexpression of miR-146a in hippocampal microglia via IRAK1/TRAF6/NF-κB pathway improves cognitive function in diabetic mice - Zhang, Jingyu; Lin, Xiaoyun; Huang, Qing; Fu, Zhang; Huang, Yihuan; Chen, Zhiqing; Li, Ningning; Lin, Xiahong (Experimental neurology, 2025)
Keywords: Animals; Cognition - physiology; Cognitive dysfunction; Cognitive Dysfunction - metabolism; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - psychology; Diabetic encephalopathy; Hippocampus - metabolism; Interleukin-1 Receptor-Associated Kinases - biosynthesis; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-1 Receptor-Associated Kinases - metabolism; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - metabolism; MicroRNAs - biosynthesis; MicroRNAs - genetics; MicroRNAs - metabolism; miR-146a; Neuroimmune; NF-kappa B - biosynthesis; NF-kappa B - metabolism; Signal Transduction - physiology; TNF Receptor-Associated Factor 6 - biosynthesis; TNF Receptor-Associated Factor 6 - metabolism; miR-146a; Diabetic encephalopathy; Neuroimmune; Cognitive dysfunction; Microglia