In silico screening of anticholinesterase alkaloids for cyclooxygenase-2 (COX-2) and matrix metalloproteinase 8 (MMP-8) inhibitory potentials as multi-target inhibitors of Alzheimer’s disease

• Published in: Medicinal chemistry research Vol. 28; no. 10; pp. 1704 - 1717
• Main Authors: Ishola, Ahmed A., Adewole, Kayode E
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2019; Springer Nature B.V
• Subjects: Affinity; Alkaloids; Alzheimer's disease; Binding; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cyclooxygenase-2; Excretion; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; Molecular docking; Molecular interactions; Neurodegenerative diseases; Neutrophil collagenase; Original Research; Pharmacology/Toxicology; Proteins; Signs and symptoms; Anticholinesterase; Alkaloids; Cyclooxygenase; Matrix metalloproteinase 8; Molecular docking

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with yet no effective drug treatment; although several anticholinesterases are being used to offer relief from the symptoms of the disease. Recent studies have indicated that over-activation of cyclooxygenase-2 (COX-2) and matrix m...