Oxytocin alleviates high-fat diet-induced anxiety by decreasing glutamatergic synaptic transmission in the ventral dentate gyrus in adolescent mice

• Published in: Neuropharmacology Vol. 262; p. 110201
• Main Authors: Cao, Xi, Wang, Qiyuan, Zhang, Lina, Sun, Huichao, Xu, Gang, Chen, Xiao, Wu, Zhihong, Liu, Huibao, Yuan, Gaole, Wu, Jian, Liu, Tao
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2025
• Subjects: Adolescence; Anxiety; High-fat diet; Oxytocin; Ventral dentate gyrus; Adolescence; Anxiety; Oxytocin; Ventral dentate gyrus; High-fat diet

A high-fat diet (HFD)-induced obesity is associated with mental disorders in adolescence. However, the mechanisms underlying these associations remain unclear. In this study, we hypothesized that synaptic remodeling occurs in the ventral hippocampus (vHP) of obese mice. To investigate this, we estab...