Passive Cavitation Enhancement Mapping via an Ultrasound Dual-Mode phased array to monitor blood-brain barrier opening

• Published in: Journal of medical and biological engineering Vol. 42; no. 6; pp. 757 - 766
• Main Authors: Hoang, Trung Nguyen, Lin, Hsiang-Ching, Tsai, Chih-Hong, Jan, Cheng-Kai, Liu, Hao-Li
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Biological Techniques; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biomedicine; Blood-brain barrier; Cavitation; Central nervous system; Central nervous system diseases; Frequencies; Mapping; Neuroimaging; Original Article; Phased arrays; Quality assurance; Receiving; Regenerative Medicine/Tissue Engineering; Ultrasonic imaging; Ultrasonic testing; Ultrasound; Phased array; Focused ultrasound; Microbubble; Dual transmit/ received mode; Blood-brain barrier; Acoustic cavitation

Purpose Focused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to improve central nervous system disease treatment. Since BBB opening also highly correlates with the microbubble-induced stable cavitation, in t...