Passive Cavitation Enhancement Mapping via an Ultrasound Dual-Mode phased array to monitor blood-brain barrier opening
Purpose Focused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to improve central nervous system disease treatment. Since BBB opening also highly correlates with the microbubble-induced stable cavitation, in t...
Saved in:
Published in | Journal of medical and biological engineering Vol. 42; no. 6; pp. 757 - 766 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.12.2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Purpose
Focused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to improve central nervous system disease treatment. Since BBB opening also highly correlates with the microbubble-induced stable cavitation, in this study, we aim to realize and implement the construction of cavitation-related passive mapping under the structure of a dual-mode phased array structure for the guidance of the focused ultrasound BBB-opening treatment.
Methods
A sparse distributed (48 out of a total of 256) receiving configuration was implemented to be functioned as dual-mode transmitting and receiving in the structure. The centered transmission locates at 400 kHz, whereas its 0.5x subharmonics (200 kHz), fundamental (400 kHz), 1.5x ultraharmonic (600 kHz), and 2nd harmonics (800 kHz) have been received and characterized. We demonstrated the capability of correlating the signal intensity with a wide range of microbubble concentrations in the in-vitro setup. In in-vivo verifications, a total of 9 animal experiments have been conducted to implement the passive cavitation mapping to correlate the imaging intensity with the occurrence of the outcome to induce blood-brain barrier opening.
Results
Ultraharmonics provided superior sensitivity and detectability to microbubble-related cavitation activity than the other selected frequency band, suggesting the potential in predicting BBB opening outcomes based on the passive image.
Conclusion
Cavitation mapping implemented by dual-mode ultrasound phased array is feasible and can provide assure the treatment quality in opening the blood-brain barrier in the brain. |
---|---|
AbstractList | Purpose
Focused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to improve central nervous system disease treatment. Since BBB opening also highly correlates with the microbubble-induced stable cavitation, in this study, we aim to realize and implement the construction of cavitation-related passive mapping under the structure of a dual-mode phased array structure for the guidance of the focused ultrasound BBB-opening treatment.
Methods
A sparse distributed (48 out of a total of 256) receiving configuration was implemented to be functioned as dual-mode transmitting and receiving in the structure. The centered transmission locates at 400 kHz, whereas its 0.5x subharmonics (200 kHz), fundamental (400 kHz), 1.5x ultraharmonic (600 kHz), and 2nd harmonics (800 kHz) have been received and characterized. We demonstrated the capability of correlating the signal intensity with a wide range of microbubble concentrations in the in-vitro setup. In in-vivo verifications, a total of 9 animal experiments have been conducted to implement the passive cavitation mapping to correlate the imaging intensity with the occurrence of the outcome to induce blood-brain barrier opening.
Results
Ultraharmonics provided superior sensitivity and detectability to microbubble-related cavitation activity than the other selected frequency band, suggesting the potential in predicting BBB opening outcomes based on the passive image.
Conclusion
Cavitation mapping implemented by dual-mode ultrasound phased array is feasible and can provide assure the treatment quality in opening the blood-brain barrier in the brain. PurposeFocused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to improve central nervous system disease treatment. Since BBB opening also highly correlates with the microbubble-induced stable cavitation, in this study, we aim to realize and implement the construction of cavitation-related passive mapping under the structure of a dual-mode phased array structure for the guidance of the focused ultrasound BBB-opening treatment.MethodsA sparse distributed (48 out of a total of 256) receiving configuration was implemented to be functioned as dual-mode transmitting and receiving in the structure. The centered transmission locates at 400 kHz, whereas its 0.5x subharmonics (200 kHz), fundamental (400 kHz), 1.5x ultraharmonic (600 kHz), and 2nd harmonics (800 kHz) have been received and characterized. We demonstrated the capability of correlating the signal intensity with a wide range of microbubble concentrations in the in-vitro setup. In in-vivo verifications, a total of 9 animal experiments have been conducted to implement the passive cavitation mapping to correlate the imaging intensity with the occurrence of the outcome to induce blood-brain barrier opening.ResultsUltraharmonics provided superior sensitivity and detectability to microbubble-related cavitation activity than the other selected frequency band, suggesting the potential in predicting BBB opening outcomes based on the passive image.ConclusionCavitation mapping implemented by dual-mode ultrasound phased array is feasible and can provide assure the treatment quality in opening the blood-brain barrier in the brain. |
Author | Hoang, Trung Nguyen Tsai, Chih-Hong Liu, Hao-Li Lin, Hsiang-Ching Jan, Cheng-Kai |
Author_xml | – sequence: 1 givenname: Trung Nguyen surname: Hoang fullname: Hoang, Trung Nguyen organization: Department of Electrical Engineering, Chang Gung University – sequence: 2 givenname: Hsiang-Ching surname: Lin fullname: Lin, Hsiang-Ching organization: Department of Electrical Engineering, National Taiwan University – sequence: 3 givenname: Chih-Hong surname: Tsai fullname: Tsai, Chih-Hong organization: Department of Electrical Engineering, National Taiwan University – sequence: 4 givenname: Cheng-Kai surname: Jan fullname: Jan, Cheng-Kai organization: Department of Electrical Engineering, Chang Gung University – sequence: 5 givenname: Hao-Li orcidid: 0000-0003-1541-1227 surname: Liu fullname: Liu, Hao-Li email: hlliu@ntu.edu.tw organization: Department of Electrical Engineering, National Taiwan University |
BookMark | eNp9kE1LJDEQhoO4sKPrH9hTwHPcStKddB9l_FpQ9LCeQ3W6RiMzSZv0DPjvNzqCN-tSFO9HwXPEDmOKxNhvCWcSwP4pDXSNEaCUqKduhTpgCyX7XjS2tYdsIQ30Avqu_clOSnmBOro3RnYLtnvAUsKO-BJ3YcY5pMgv4zNGTxuKM7_DaQrxie8Ccoz8cT1nLGkbR36xxbW4SyPx6RkLjRxzxjc-J75JMcwp82Gd0iiGjCHyoaqBMk8Txdr3i_1Y4brQyec-Zo9Xl_-WN-L2_vrv8vxWeC37WaAaAVqtOzToB7_ySNbLVrYNKAktGUO6QW1HlF7bwZCxEgdYQQ8d-aocs9N975TT65bK7F7SNsf60inbWNCdUaq61N7lcyol08pNOWwwvzkJ7h2x2yN2FbH7QOzeQ3ofKtUcnyh_VX-T-g9vrIGp |
CitedBy_id | crossref_primary_10_1007_s40846_022_00765_w |
Cites_doi | 10.1016/j.jconrel.2016.05.052 10.1109/TBME.2010.2050483 10.1109/tuffc.2016.2620492 10.1088/0031-9155/55/20/007 10.1088/0031-9155/61/17/r206 10.1177/016173460602800201 10.1371/journal.pone.0114311 10.1371/journal.pone.0058995 10.1371/journal.pone.0045783 10.1148/radiol.11111417 10.1109/tbme.2014.2300838 10.1016/j.biomaterials.2013.01.099 10.1088/0031-9155/61/7/2926 10.1016/j.ultrasmedbio.2006.05.015 10.1016/j.neuroimage.2004.06.046 10.1016/j.ultrasmedbio.2015.08.014 10.1109/TUFFC.2014.006882 10.1073/pnas.1003388107 10.1088/0031-9155/61/24/8476 10.1602/neurorx.2.1.1 10.1109/TBME.2014.2305723 10.1371/journal.pone.0057682 10.1038/srep27939 10.1109/tuffc.2018.2855181 10.1148/radiol.2016152444 10.3389/fphar.2019.00086 10.1109/TBME.2008.925697 10.1109/TBME.2013.2264484 10.1002/ijc.22732 10.1016/j.jconrel.2015.06.010 10.1101/cshperspect.a020412 10.1016/j.ultrasmedbio.2004.04.010 10.1016/j.ultrasmedbio.2005.07.010 10.1073/pnas.0604318103 10.1088/0031-9155/51/4/003 |
ContentType | Journal Article |
Copyright | Taiwanese Society of Biomedical Engineering 2022 Taiwanese Society of Biomedical Engineering 2022. |
Copyright_xml | – notice: Taiwanese Society of Biomedical Engineering 2022 – notice: Taiwanese Society of Biomedical Engineering 2022. |
DBID | AAYXX CITATION K9. |
DOI | 10.1007/s40846-022-00735-2 |
DatabaseName | CrossRef ProQuest Health & Medical Complete (Alumni) |
DatabaseTitle | CrossRef ProQuest Health & Medical Complete (Alumni) |
DatabaseTitleList | ProQuest Health & Medical Complete (Alumni) |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering |
EISSN | 2199-4757 |
EndPage | 766 |
ExternalDocumentID | 10_1007_s40846_022_00735_2 |
GrantInformation_xml | – fundername: Ministry of Science and Technology, Taiwan grantid: 110-2321-B-002-010 funderid: http://dx.doi.org/10.13039/501100004663 – fundername: Ministry of Science and Technology grantid: 108-2221-E-002 -175 -MY3 funderid: http://dx.doi.org/10.13039/100007225 |
GroupedDBID | --- -EM 188 203 2UF 4.4 406 53G 8RM 9RA AAAVM AAFGU AAHNG AAIAL AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO AAZMS ABDZT ABECU ABFGW ABFTV ABJNI ABJOX ABKAS ABKCH ABMQK ABQBU ABTEG ABTKH ABTMW ABXPI ACBMV ACBRV ACBYP ACGFS ACHSB ACIGE ACIPQ ACIWK ACKNC ACMLO ACOKC ACPRK ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADINQ ADKNI ADKPE ADMDM ADOXG ADTPH ADURQ ADYFF ADZKW AEBTG AEFTE AEJHL AEJRE AENEX AEOHA AEPYU AESKC AESTI AETCA AEVLU AEVTX AEXYK AFNRJ AFQWF AFZKB AGAYW AGDGC AGGBP AGMZJ AGQMX AGWZB AGYKE AHAVH AHBYD AHKAY AHSBF AIAKS AILAN AIMYW AINHJ AITGF AJBLW AJDOV AJRNO AJZVZ AKQUC ALFXC ALMA_UNASSIGNED_HOLDINGS AMKLP AMXSW AMYLF AMYQR ANMIH ASPBG ATFKH AUKKA AVWKF AVXWI AXYYD BAWUL BGNMA CEFSP CNMHZ CSCUP DNIVK DPUIP EBLON EBS EIOEI EJD ESBYG FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FYJPI GGCAI GGRSB GJIRD GQ6 HRMNR IKXTQ IWAJR IXD J-C JBSCW JZLTJ KOV LLZTM M4Y NPVJJ NQJWS NU0 O9J P2P PT4 RLLFE RSV SHX SISQX SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW STPWE TSG TUXDW UG4 UOJIU UTJUX UZ5 UZXMN VFIZW Z7X Z83 ZMTXR 0R~ AACDK AAJBT AASML AAYXX ABAKF ACAOD ACDTI ACZOJ AEFQL AEMSY AFBBN AGQEE AGRTI AIGIU CITATION HG6 ROL SJYHP K9. |
ID | FETCH-LOGICAL-c319t-a2d005338a6acbcfcae7c1515402105e66e34a37da1c37b6e671ab0f0908ec4a3 |
IEDL.DBID | AGYKE |
ISSN | 1609-0985 |
IngestDate | Thu Oct 10 15:53:44 EDT 2024 Thu Sep 12 16:47:37 EDT 2024 Sat Dec 16 12:06:00 EST 2023 |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 6 |
Keywords | Phased array Focused ultrasound Microbubble Dual transmit/ received mode Blood-brain barrier Acoustic cavitation |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c319t-a2d005338a6acbcfcae7c1515402105e66e34a37da1c37b6e671ab0f0908ec4a3 |
ORCID | 0000-0003-1541-1227 |
PQID | 2747038622 |
PQPubID | 2044285 |
PageCount | 10 |
ParticipantIDs | proquest_journals_2747038622 crossref_primary_10_1007_s40846_022_00735_2 springer_journals_10_1007_s40846_022_00735_2 |
PublicationCentury | 2000 |
PublicationDate | 2022-12-01 |
PublicationDateYYYYMMDD | 2022-12-01 |
PublicationDate_xml | – month: 12 year: 2022 text: 2022-12-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Berlin/Heidelberg |
PublicationPlace_xml | – name: Berlin/Heidelberg – name: Heidelberg |
PublicationTitle | Journal of medical and biological engineering |
PublicationTitleAbbrev | J. Med. Biol. Eng |
PublicationYear | 2022 |
Publisher | Springer Berlin Heidelberg Springer Nature B.V |
Publisher_xml | – name: Springer Berlin Heidelberg – name: Springer Nature B.V |
References | Chen, Wei, Liu (CR2) 2019; 10 Haritonova, Liu, Ebbini (CR34) 2015; 62 McDannold, Vykhodtseva, Raymond, Jolesz, Hynynen (CR4) 2005; 31 Hynynen, McDannold, Sheikov, Jolesz, Vykhodtseva (CR5) 2005; 24 Arvanitis, Livingstone, Vykhodtseva, McDannold (CR22) 2012; 7 McDannold, Vykhodtseva, Hynynen (CR18) 2006; 51 Ebbini, Yao, Shrestha (CR32) 2006; 28 O’Reilly, Hynynen (CR20) 2010; 57 Liu (CR29) 2014; 61 Wei (CR7) 2013; 8 Liu, Huang, Chen, Wang, Chen, Wei (CR8) 2014; 9 Pardridge (CR15) 2005; 2 O’Reilly, Hynynen (CR21) 2012; 263 Xia, Tsui, Liu (CR25) 2016; 6 Treat, McDannold, Vykhodtseva, Zhang, Tam, Hynynen (CR6) 2007; 121 Sheikov, McDannold, Jolesz, Zhang, Tam, Hynynen (CR16) 2006; 32 Liu (CR27) 2018; 65 Liu (CR10) 2016; 281 Lin (CR3) 2015; 212 Tsai, Zhang, Liao, Liu (CR35) 2016; 61 Fan (CR12) 2013; 34 Lin (CR14) 2016; 235 Sheikov, McDannold, Vykhodtseva, Jolesz, Hynynen (CR17) 2004; 30 Liu (CR11) 2010; 107 Hsu (CR13) 2013; 8 Haworth, Bader, Rich, Holland, Mast (CR23) 2017; 64 Hynynen, Jones (CR28) 2016; 61 Haworth (CR24) 2016; 42 Liu, Chen, Kuo, Huang (CR30) 2008; 55 Deng, O’Reilly, Jones, An, Hynynen (CR26) 2016; 61 O’Reilly, Jones, Hynynen (CR31) 2014; 61 Kinoshita, McDannold, Jolesz, Hynynen (CR9) 2006; 103 Daneman, Prat (CR1) 2015; 7 Tung, Vlachos, Choi, Deffieux, Selert, Konofagou (CR19) 2010; 55 Casper, Liu, Ballard, Ebbini (CR33) 2013; 60 ES Ebbini (735_CR32) 2006; 28 M Kinoshita (735_CR9) 2006; 103 HL Liu (735_CR29) 2014; 61 CD Arvanitis (735_CR22) 2012; 7 R Daneman (735_CR1) 2015; 7 HL Liu (735_CR11) 2010; 107 L Deng (735_CR26) 2016; 61 K Hynynen (735_CR28) 2016; 61 KT Chen (735_CR2) 2019; 10 CY Lin (735_CR3) 2015; 212 K Hynynen (735_CR5) 2005; 24 MA O’Reilly (735_CR20) 2010; 57 KJ Haworth (735_CR24) 2016; 42 LH Treat (735_CR6) 2007; 121 HL Liu (735_CR27) 2018; 65 HL Liu (735_CR10) 2016; 281 MA O’Reilly (735_CR21) 2012; 263 N Sheikov (735_CR16) 2006; 32 MA O’Reilly (735_CR31) 2014; 61 N Sheikov (735_CR17) 2004; 30 PH Hsu (735_CR13) 2013; 8 CH Fan (735_CR12) 2013; 34 HL Liu (735_CR8) 2014; 9 N McDannold (735_CR18) 2006; 51 N McDannold (735_CR4) 2005; 31 CY Lin (735_CR14) 2016; 235 WM Pardridge (735_CR15) 2005; 2 YS Tung (735_CR19) 2010; 55 A Haritonova (735_CR34) 2015; 62 J Xia (735_CR25) 2016; 6 AJ Casper (735_CR33) 2013; 60 KC Wei (735_CR7) 2013; 8 KJ Haworth (735_CR23) 2017; 64 HL Liu (735_CR30) 2008; 55 CH Tsai (735_CR35) 2016; 61 |
References_xml | – volume: 235 start-page: 72 year: 2016 end-page: 81 ident: CR14 article-title: Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson’s disease mouse model publication-title: Journal Of Controlled Release : Official Journal Of The Controlled Release Society doi: 10.1016/j.jconrel.2016.05.052 contributor: fullname: Lin – volume: 57 start-page: 2286 issue: 9 year: 2010 end-page: 2294 ident: CR20 article-title: A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2010.2050483 contributor: fullname: Hynynen – volume: 64 start-page: 177 issue: 1 year: 2017 end-page: 191 ident: CR23 article-title: Quantitative Frequency-Domain Passive Cavitation Imaging publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/tuffc.2016.2620492 contributor: fullname: Mast – volume: 55 start-page: 6141 issue: 20 year: 2010 end-page: 6155 ident: CR19 article-title: In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/55/20/007 contributor: fullname: Konofagou – volume: 61 start-page: R206 issue: 17 year: 2016 end-page: R248 ident: CR28 article-title: Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/17/r206 contributor: fullname: Jones – volume: 28 start-page: 65 issue: 2 year: 2006 end-page: 82 ident: CR32 article-title: Dual-mode ultrasound phased arrays for image-guided surgery publication-title: Ultrasonic imaging doi: 10.1177/016173460602800201 contributor: fullname: Shrestha – volume: 9 start-page: e114311 issue: 12 year: 2014 ident: CR8 article-title: Pharmacodynamic and therapeutic investigation of focused ultrasound-induced blood-brain barrier opening for enhanced temozolomide delivery in glioma treatment publication-title: PLoS One doi: 10.1371/journal.pone.0114311 contributor: fullname: Wei – volume: 8 start-page: e58995 issue: 3 year: 2013 ident: CR7 article-title: Focused ultrasound-induced blood-brain barrier opening to enhance temozolomide delivery for glioblastoma treatment: a preclinical study publication-title: PLoS One doi: 10.1371/journal.pone.0058995 contributor: fullname: Wei – volume: 7 start-page: 57 issue: 9 year: 2012 end-page: 83 ident: CR22 article-title: Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring publication-title: PLoS One doi: 10.1371/journal.pone.0045783 contributor: fullname: McDannold – volume: 263 start-page: 96 issue: 1 year: 2012 end-page: 106 ident: CR21 article-title: Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller publication-title: Radiology doi: 10.1148/radiol.11111417 contributor: fullname: Hynynen – volume: 61 start-page: 1285 issue: 4 year: 2014 end-page: 1294 ident: CR31 article-title: Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/tbme.2014.2300838 contributor: fullname: Hynynen – volume: 34 start-page: 3706 issue: 14 year: 2013 end-page: 3715 ident: CR12 article-title: SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.01.099 contributor: fullname: Fan – volume: 61 start-page: 2926 issue: 7 year: 2016 end-page: 2946 ident: CR35 article-title: Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: implementation of confocal dual-frequency piezoelectric transducers publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/7/2926 contributor: fullname: Liu – volume: 32 start-page: 399 issue: 9 year: 2006 end-page: 409 ident: CR16 article-title: Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2006.05.015 contributor: fullname: Hynynen – volume: 24 start-page: 12 issue: 1 year: 2005 end-page: 20 ident: CR5 article-title: Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.06.046 contributor: fullname: Vykhodtseva – volume: 42 start-page: 18 issue: 2 year: 2016 end-page: 27 ident: CR24 article-title: Trans-Stent B-Mode Ultrasound and Passive Cavitation Imaging publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2015.08.014 contributor: fullname: Haworth – volume: 62 start-page: 2031 issue: 12 year: 2015 end-page: 2042 ident: CR34 article-title: In Vivo application and localization of transcranial focused ultrasound using dual-mode ultrasound arrays publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/TUFFC.2014.006882 contributor: fullname: Ebbini – volume: 107 start-page: 15205 issue: 34 year: 2010 end-page: 15210 ident: CR11 article-title: Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1003388107 contributor: fullname: Liu – volume: 61 start-page: 8476 issue: 24 year: 2016 end-page: 8501 ident: CR26 article-title: A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/24/8476 contributor: fullname: Hynynen – volume: 2 start-page: 1 issue: 1 year: 2005 end-page: 2 ident: CR15 article-title: The blood-brain barrier and neurotherapeutics publication-title: NeuroRx: the journal of the American Society for Experimental NeuroTherapeutics doi: 10.1602/neurorx.2.1.1 contributor: fullname: Pardridge – volume: 61 start-page: 1350 issue: 4 year: 2014 end-page: 1360 ident: CR29 article-title: Design and experimental evaluation of a 256-channel dual-frequency ultrasound phased-array system for transcranial blood-brain barrier opening and brain drug delivery publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2014.2305723 contributor: fullname: Liu – volume: 8 start-page: 76 issue: 2 year: 2013 end-page: 82 ident: CR13 article-title: Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound publication-title: PLoS One doi: 10.1371/journal.pone.0057682 contributor: fullname: Hsu – volume: 6 start-page: 27939 year: 2016 ident: CR25 article-title: Low-Pressure Burst-Mode Focused Ultrasound Wave Reconstruction and Mapping for Blood-Brain Barrier Opening: A Preclinical Examination publication-title: Scientific Reports doi: 10.1038/srep27939 contributor: fullname: Liu – volume: 65 start-page: 1756 issue: 10 year: 2018 end-page: 1767 ident: CR27 article-title: Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/tuffc.2018.2855181 contributor: fullname: Liu – volume: 281 start-page: 99 issue: 1 year: 2016 end-page: 108 ident: CR10 article-title: Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment publication-title: Radiology doi: 10.1148/radiol.2016152444 contributor: fullname: Liu – volume: 10 start-page: 86 year: 2019 ident: CR2 article-title: Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment publication-title: Frontiers In Pharmacology doi: 10.3389/fphar.2019.00086 contributor: fullname: Liu – volume: 55 start-page: 2407 issue: 10 year: 2008 end-page: 2416 ident: CR30 article-title: Design and experimental evaluations of a low-frequency hemispherical ultrasound phased-array system for transcranial blood-brain barrier disruption publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2008.925697 contributor: fullname: Huang – volume: 60 start-page: 2751 issue: 10 year: 2013 end-page: 2759 ident: CR33 article-title: Real-time implementation of a dual-mode ultrasound array system: in vivo results publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2013.2264484 contributor: fullname: Ebbini – volume: 121 start-page: 901 issue: 4 year: 2007 end-page: 907 ident: CR6 article-title: Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound publication-title: International journal of cancer doi: 10.1002/ijc.22732 contributor: fullname: Hynynen – volume: 212 start-page: 1 year: 2015 end-page: 9 ident: CR3 article-title: Focused ultrasound-induced blood-brain barrier opening for non-viral, non-invasive, and targeted gene delivery publication-title: Journal Of Controlled Release : Official Journal Of The Controlled Release Society doi: 10.1016/j.jconrel.2015.06.010 contributor: fullname: Lin – volume: 7 start-page: a020412 issue: 1 year: 2015 end-page: a020412 ident: CR1 article-title: The blood-brain barrier publication-title: Cold Spring Harbor Perspectives In Biology doi: 10.1101/cshperspect.a020412 contributor: fullname: Prat – volume: 30 start-page: 79 issue: 7 year: 2004 end-page: 89 ident: CR17 article-title: Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2004.04.010 contributor: fullname: Hynynen – volume: 31 start-page: 1527 issue: 11 year: 2005 end-page: 1537 ident: CR4 article-title: MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2005.07.010 contributor: fullname: Hynynen – volume: 103 start-page: 11719 issue: 31 year: 2006 end-page: 11723 ident: CR9 article-title: Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0604318103 contributor: fullname: Hynynen – volume: 51 start-page: 793 issue: 4 year: 2006 end-page: 807 ident: CR18 article-title: Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/51/4/003 contributor: fullname: Hynynen – volume: 60 start-page: 2751 issue: 10 year: 2013 ident: 735_CR33 publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2013.2264484 contributor: fullname: AJ Casper – volume: 57 start-page: 2286 issue: 9 year: 2010 ident: 735_CR20 publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2010.2050483 contributor: fullname: MA O’Reilly – volume: 212 start-page: 1 year: 2015 ident: 735_CR3 publication-title: Journal Of Controlled Release : Official Journal Of The Controlled Release Society doi: 10.1016/j.jconrel.2015.06.010 contributor: fullname: CY Lin – volume: 62 start-page: 2031 issue: 12 year: 2015 ident: 735_CR34 publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/TUFFC.2014.006882 contributor: fullname: A Haritonova – volume: 24 start-page: 12 issue: 1 year: 2005 ident: 735_CR5 publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.06.046 contributor: fullname: K Hynynen – volume: 42 start-page: 18 issue: 2 year: 2016 ident: 735_CR24 publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2015.08.014 contributor: fullname: KJ Haworth – volume: 9 start-page: e114311 issue: 12 year: 2014 ident: 735_CR8 publication-title: PLoS One doi: 10.1371/journal.pone.0114311 contributor: fullname: HL Liu – volume: 65 start-page: 1756 issue: 10 year: 2018 ident: 735_CR27 publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/tuffc.2018.2855181 contributor: fullname: HL Liu – volume: 10 start-page: 86 year: 2019 ident: 735_CR2 publication-title: Frontiers In Pharmacology doi: 10.3389/fphar.2019.00086 contributor: fullname: KT Chen – volume: 61 start-page: 1285 issue: 4 year: 2014 ident: 735_CR31 publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/tbme.2014.2300838 contributor: fullname: MA O’Reilly – volume: 7 start-page: a020412 issue: 1 year: 2015 ident: 735_CR1 publication-title: Cold Spring Harbor Perspectives In Biology doi: 10.1101/cshperspect.a020412 contributor: fullname: R Daneman – volume: 51 start-page: 793 issue: 4 year: 2006 ident: 735_CR18 publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/51/4/003 contributor: fullname: N McDannold – volume: 6 start-page: 27939 year: 2016 ident: 735_CR25 publication-title: Scientific Reports doi: 10.1038/srep27939 contributor: fullname: J Xia – volume: 121 start-page: 901 issue: 4 year: 2007 ident: 735_CR6 publication-title: International journal of cancer doi: 10.1002/ijc.22732 contributor: fullname: LH Treat – volume: 7 start-page: 57 issue: 9 year: 2012 ident: 735_CR22 publication-title: PLoS One doi: 10.1371/journal.pone.0045783 contributor: fullname: CD Arvanitis – volume: 61 start-page: 2926 issue: 7 year: 2016 ident: 735_CR35 publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/7/2926 contributor: fullname: CH Tsai – volume: 28 start-page: 65 issue: 2 year: 2006 ident: 735_CR32 publication-title: Ultrasonic imaging doi: 10.1177/016173460602800201 contributor: fullname: ES Ebbini – volume: 107 start-page: 15205 issue: 34 year: 2010 ident: 735_CR11 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1003388107 contributor: fullname: HL Liu – volume: 103 start-page: 11719 issue: 31 year: 2006 ident: 735_CR9 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0604318103 contributor: fullname: M Kinoshita – volume: 263 start-page: 96 issue: 1 year: 2012 ident: 735_CR21 publication-title: Radiology doi: 10.1148/radiol.11111417 contributor: fullname: MA O’Reilly – volume: 281 start-page: 99 issue: 1 year: 2016 ident: 735_CR10 publication-title: Radiology doi: 10.1148/radiol.2016152444 contributor: fullname: HL Liu – volume: 30 start-page: 79 issue: 7 year: 2004 ident: 735_CR17 publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2004.04.010 contributor: fullname: N Sheikov – volume: 55 start-page: 2407 issue: 10 year: 2008 ident: 735_CR30 publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2008.925697 contributor: fullname: HL Liu – volume: 61 start-page: 1350 issue: 4 year: 2014 ident: 735_CR29 publication-title: IEEE transactions on bio-medical engineering doi: 10.1109/TBME.2014.2305723 contributor: fullname: HL Liu – volume: 31 start-page: 1527 issue: 11 year: 2005 ident: 735_CR4 publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2005.07.010 contributor: fullname: N McDannold – volume: 64 start-page: 177 issue: 1 year: 2017 ident: 735_CR23 publication-title: Ieee Transactions On Ultrasonics, Ferroelectrics, And Frequency Control doi: 10.1109/tuffc.2016.2620492 contributor: fullname: KJ Haworth – volume: 61 start-page: 8476 issue: 24 year: 2016 ident: 735_CR26 publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/24/8476 contributor: fullname: L Deng – volume: 8 start-page: e58995 issue: 3 year: 2013 ident: 735_CR7 publication-title: PLoS One doi: 10.1371/journal.pone.0058995 contributor: fullname: KC Wei – volume: 34 start-page: 3706 issue: 14 year: 2013 ident: 735_CR12 publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.01.099 contributor: fullname: CH Fan – volume: 235 start-page: 72 year: 2016 ident: 735_CR14 publication-title: Journal Of Controlled Release : Official Journal Of The Controlled Release Society doi: 10.1016/j.jconrel.2016.05.052 contributor: fullname: CY Lin – volume: 8 start-page: 76 issue: 2 year: 2013 ident: 735_CR13 publication-title: PLoS One doi: 10.1371/journal.pone.0057682 contributor: fullname: PH Hsu – volume: 32 start-page: 399 issue: 9 year: 2006 ident: 735_CR16 publication-title: Ultrasound In Medicine And Biology doi: 10.1016/j.ultrasmedbio.2006.05.015 contributor: fullname: N Sheikov – volume: 61 start-page: R206 issue: 17 year: 2016 ident: 735_CR28 publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/61/17/r206 contributor: fullname: K Hynynen – volume: 55 start-page: 6141 issue: 20 year: 2010 ident: 735_CR19 publication-title: Physics In Medicine & Biology doi: 10.1088/0031-9155/55/20/007 contributor: fullname: YS Tung – volume: 2 start-page: 1 issue: 1 year: 2005 ident: 735_CR15 publication-title: NeuroRx: the journal of the American Society for Experimental NeuroTherapeutics doi: 10.1602/neurorx.2.1.1 contributor: fullname: WM Pardridge |
SSID | ssj0000396618 |
Score | 2.3133283 |
Snippet | Purpose
Focused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to... PurposeFocused ultrasound with the presence of microbubbles has been shown to temporarily open the blood-brain barrier (BBB), which offers the potential to... |
SourceID | proquest crossref springer |
SourceType | Aggregation Database Publisher |
StartPage | 757 |
SubjectTerms | Biological Techniques Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical Engineering/Biotechnology Biomedicine Blood-brain barrier Cavitation Central nervous system Central nervous system diseases Frequencies Mapping Neuroimaging Original Article Phased arrays Quality assurance Receiving Regenerative Medicine/Tissue Engineering Ultrasonic imaging Ultrasonic testing Ultrasound |
Title | Passive Cavitation Enhancement Mapping via an Ultrasound Dual-Mode phased array to monitor blood-brain barrier opening |
URI | https://link.springer.com/article/10.1007/s40846-022-00735-2 https://www.proquest.com/docview/2747038622 |
Volume | 42 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV07T8MwELZQWWDgjXjLAxsYOU3iuGNVWhAIxEAlmKLzI4AoAYW0Evx6fG7S8hyYL7KUO_ve9x0h-0IbnUkbsCAJDYus5EwaFTNjskgEUsXWlwsuLsVpPzq7iW-mc9y-2b2uSHpFPZl1i7gzlQybz7G6FDOnd2djBPxqkNn2ye35NLXCQ-fD-8xeIDD135JxNS7z-0FfTdLUz_xWGvUWp7dIruu5nXGjyePRsFRH-v0njON_fmaJLFQeKG2Pr8wymbH5Cpn_hEu4SkZXzqV2apB2YFRheNNufo8XBJOJ9AIQ1eGOjh6AQk77g7KAV9zPRI-HMGC4X42-3Dv7aCgUBbzR8pk-eeVR0HGnvMLNFFQ5qjPLFFd4ufPWSL_Xve6csmpBA9Pu5ZYMmsbP8koQoJXONNhEo4cUYSQZWyFsGEGYGAh0mChhRRKA4hlvcWm1o6yTRv6c2w1CJXDgSsRYpUTAHMmzptYyU2GkIq7NJjmoZZS-jHE40gnisudm6riZem6mzU2yU4sxrd7ka4rxNw9dBOfIh7VYpuS_T9v63-fbZK6JkvU9LzukURZDu-s8l1LtVTf1A3Ye5DI |
link.rule.ids | 315,786,790,27955,27956,41114,42183,52144 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LTxsxELZQOEAPtBSqQoH60Fsx8ma9XnNEQJqSBHEgEpxW48cSVFjQZhOJ_vp6nN2EIjhwnpXl9YxnxvP4hpAf0liTKxexKI0tE05xpqxOmLW5kJHSiQvpgsG57A7F2VVyVTeFjZtq9yYlGTT1vNlNcG8rGVafY3opYV7xLgu08C2yfPTrureIrfDYO_EhtBdJjP0fqqTul3l9of9t0sLRfJEbDSan85EMm83OKk3-HEwqfWD-vsBxfO_ffCJrtQ9Kj2ZCs06WXPGZfHiGTLhBphfeqfaKkB7DtEbxpqfFCEUEw4l0AIjrcEOnt0ChoMO7qoQxTmiiJxO4YzhhjT6OvIW0FMoSnmj1QO-D-ijprFZe42wKqj3VG2aKQ7z8eptk2Dm9PO6yekQDM_7uVgzaNnTzKpBgtMkNuNSgjyTwLZk4KV0sIE4tRCZOtXQyjUDznB9y5YynfCGt4qFwXwlVwIFrmWCeEiFzFM_bxqhcx0ILbuwW-dkwKXucIXFkc8zlcJqZP80snGbW3iI7DR-z-laOM3yB89i_4Tx5v2HLgvz2atvv-_w7WeleDvpZ__d57xtZbSOXQwXMDmlV5cTtej-m0nu12P4D8rToBg |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9wwDI_QIaHxwAYbAgYjD3tjgfSaprnHE3DjYyAeOIk9Vc5HAY2VU-mdBH89cdpygLYHxLOrKLWd2I7tnwn5Lo01uXIRi9LYMuEUZ8rqhFmbCxkpnbiQLjg5lQdDcXSRXDzr4g_V7m1Ksu5pQJSmotoZ2XznqfFNcG83GVaiY6opYf4SnhX-2IoOme3__H08fWfhsXfowzNfJDEP0FNJ0zvz74Ve2qep0_kqTxrMz-AjgXbjddXJn-1xpbfNwytMx_f82Sey0PimtF8r0yKZccUSmX-GWPiZTM68s-0vSLoLkwbdm-4XV6g6-MxITwDxHi7p5BooFHR4U5Vwh5Ob6N4YbhhOXqOjK285LYWyhHta3dK_4VopaV1Dr3FmBdWe6g02xeFefr0vZDjYP989YM3oBmb8ma4YdG3o8lUgwWiTG3CpQd9JYIyZOCldLCBOLUQmTrV0Mo1A85z3uHLGU5ZJp7gt3AqhCjhwLRPMXyKUjuJ51xiV61howY1dJVutwLJRjdCRPWExB25mnptZ4GbWXSXrrUyz5rTeZRiZ89jHdp78oxXRlPz_1dbe9vkmmTvbG2S_Dk-Pv5IPXRRyKIxZJ52qHLsN795U-lujwY_eWvDh |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Passive+Cavitation+Enhancement+Mapping+via+an+Ultrasound+Dual-Mode+phased+array+to+monitor+blood-brain+barrier+opening&rft.jtitle=Journal+of+medical+and+biological+engineering&rft.au=Nguyen%2C+Hoang+Trung&rft.au=Hsiang-Ching%2C+Lin&rft.au=Chih-Hong%2C+Tsai&rft.au=Cheng-Kai%2C+Jan&rft.date=2022-12-01&rft.pub=Springer+Nature+B.V&rft.issn=1609-0985&rft.eissn=2199-4757&rft.volume=42&rft.issue=6&rft.spage=757&rft.epage=766&rft_id=info:doi/10.1007%2Fs40846-022-00735-2&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1609-0985&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1609-0985&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1609-0985&client=summon |