Design, synthesis, and antitumor activity evaluation of carbazole derivatives with potent HDAC inhibitory activity

• Published in: Medicinal chemistry research Vol. 32; no. 8; pp. 1677 - 1689
• Main Authors: Sun, Likun, Han, Leiqiang, Zhang, Liang, Chen, Chen, Zheng, Chengyun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2023; Springer Nature B.V
• Subjects: Acetylation; Anticancer properties; Antitumor activity; Antitumor agents; Apoptosis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Carbazole; Carbazoles; Caspase-3; Flow cytometry; Histone deacetylase; Histones; Inorganic Chemistry; Medicinal Chemistry; Optimization; Original Article; Pharmacology/Toxicology; Tumor cells; Tumors; HDAC inhibitory; Carbazole; Antitumor; Apoptosis

Histone deacetylase (HDAC), a key regulator in controlling the acetylation status of histone, are considered to be associated with viability, migration, invasion, proliferation and apoptosis of malignant tumors. The HDAC inhibition is an effective strategy for designing compounds against malignant t...