Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal model

• Published in: Medicinal chemistry research Vol. 31; no. 10; pp. 1740 - 1753
• Main Authors: Rajamanickam, Gayathri, SL, Manju
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2022; Springer Nature B.V
• Subjects: Acetylcholinesterase; Aluminum; Aluminum chloride; Alzheimer's disease; Animal models; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Chlorides; Enzymes; Fractionation; Inflammation; Inorganic Chemistry; Lipid peroxidation; Lipids; Liquid oxygen; Medicinal Chemistry; Molecular docking; Neurodegenerative diseases; Neurofibrillary tangles; Oral administration; Original Research; Oxidative stress; Pharmacology/Toxicology; Phyllanthus niruri; Senile plaques; Alzheimer’s disease; Acetylcholinesterase; Lipoxygenase; Niruriflavone; Aluminum chloride

Alzheimer’s disease (AD) is one of the chronic neurodegenerative pathologies that lead to memory loss and mental and behavioral changes in elderly people. The senile plaques, neurofibrillary tangles, oxidative stress, increased acetylcholinesterase (AChE), and neuroinflammation by activating 5-lipox...