Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial

• Published in: The journal of clinical psychiatry Vol. 68; no. 11; p. 1691
• Main Authors: Furieri, Fernando A, Nakamura-Palacios, Ester M
• Format: Journal Article
• Language: English
• Published: United States 01.11.2007
• Subjects: Adolescent; Adult; Aged; Alcohol Deterrents - administration & dosage; Alcohol Deterrents - pharmacology; Alcohol Deterrents - therapeutic use; Alcoholism - drug therapy; Alcoholism - epidemiology; Ambulatory Care; Amines - administration & dosage; Amines - pharmacology; Amines - therapeutic use; Blood-Brain Barrier - drug effects; Brazil - epidemiology; Cyclohexanecarboxylic Acids - administration & dosage; Cyclohexanecarboxylic Acids - pharmacology; Cyclohexanecarboxylic Acids - therapeutic use; Double-Blind Method; Drug Administration Schedule; Ethanol - adverse effects; Female; Gabapentin; gamma-Aminobutyric Acid - administration & dosage; gamma-Aminobutyric Acid - pharmacology; gamma-Aminobutyric Acid - therapeutic use; Humans; Incidence; Male; Middle Aged; Obsessive-Compulsive Disorder - drug therapy; Obsessive-Compulsive Disorder - epidemiology; Obsessive-Compulsive Disorder - psychology; Prevalence; Severity of Illness Index; Substance Withdrawal Syndrome - diagnosis; Substance Withdrawal Syndrome - epidemiology; Substance Withdrawal Syndrome - etiology; Temperance

This study examined the efficacy of a 28-day gabapentin treatment in reducing alcohol consumption and craving. A randomized, double-blind, placebo-controlled trial was performed in a Brazilian public outpatient drug treatment center, with 60 male alcohol-dependent subjects with a mean age of 44 year...