Process optimization of 1-cyanocyclohexaneacetic acid hydrogenation using response surface methodology

• Published in: Research on chemical intermediates Vol. 50; no. 11; pp. 5283 - 5303
• Main Authors: Xiong, Neng, Jiang, Lin-Li, Chen, Jia-Yu, Lin, Lei, Huang, Jin-Rong, Shen, Qi, Xue, Ya-Ping, Zheng, Yu-Guo
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.11.2024; Springer Nature B.V
• Subjects: Biological activity; Biological effects; Catalysis; Catalysts; Chemical synthesis; Chemistry; Chemistry and Materials Science; Fine chemicals; Hydrogenation; Impurities; Inorganic Chemistry; Parameter identification; Physical Chemistry; Reaction time; Response surface methodology; Substrates; Protein impurity; Response surface methodology; Gabapentin; Hydrogenation; Active pharmaceutical ingredients
• ISSN: 0922-6168; 1568-5675
• DOI: 10.1007/s11164-024-05400-8

Hydrogenation plays an important role in the production of bulk and fine chemicals. In the present work, the hydrogenation process of 1-cyanocyclohexaneacetic acid (1-CA), a key intermediate in the chemo-enzymatic synthesis of the antiepileptic drug gabapentin, was investigated. The catalysts were s...