Erbium:YAG fractional laser ablation improves cutaneous delivery of pentoxifylline from different topical dosage forms

• Published in: International journal of pharmaceutics Vol. 628; p. 122259
• Main Authors: Gou, Si, del Río-Sancho, Sergio, Laubach, Hans-Joachim, Kalia, Yogeshvar N.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.11.2022
• Subjects: Cutaneous delivery; Er:YAG fractional laser ablation; Pentoxifylline; Skin fibrosis; Topical dosage forms; Pentoxifylline; Topical dosage forms; Er:YAG fractional laser ablation; Cutaneous delivery; Skin fibrosis

[Display omitted] Topical application of pentoxifylline (PTX) would enable targeted treatment of radiation-induced skin fibrosis. However, PTX is hydrophilic with limited partitioning into the stratum corneum. The objective of this study was to investigate whether use of Erbium:YAG fractional laser...