Extended-release dexmethylphenidate 30 mg/d versus 20 mg/d: duration of attention, behavior, and performance benefits in children with attention-deficit/hyperactivity disorder

• Published in: Clinical neuropharmacology Vol. 36; no. 4; p. 117
• Main Authors: Silva, Raul R, Brams, Matthew, McCague, Kevin, Pestreich, Linda, Muniz, Rafael
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Attention - drug effects; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - physiopathology; Central Nervous System Stimulants - administration & dosage; Central Nervous System Stimulants - adverse effects; Central Nervous System Stimulants - therapeutic use; Child; Child Behavior - drug effects; Circadian Rhythm - drug effects; Cross-Over Studies; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - adverse effects; Delayed-Action Preparations - therapeutic use; Dexmethylphenidate Hydrochloride - administration & dosage; Dexmethylphenidate Hydrochloride - adverse effects; Dexmethylphenidate Hydrochloride - therapeutic use; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Educational Measurement; Female; Humans; Intention to Treat Analysis; Learning Disorders - etiology; Learning Disorders - prevention & control; Male; Mathematics; Patient Dropouts

This study aimed to compare the effects of dexmethylphenidate (D-MPH) extended-release (ER) 30 mg and D-MPH-ER 20 mg on attention, behavior, and performance in children with attention-deficit/hyperactivity disorder. In a randomized, double-blind, 3-period-by-3-treatment, crossover study, children ag...