Gene Therapy for Hepatocellular Carcinoma Using Adenoviral Vectors Delivering a Gene Encoding IL-17A-Neutralizing Antibody Fragments

• Published in: Human gene therapy Vol. 31; no. 19-20; p. 1074
• Main Authors: Zou, Haoyu, Tuhin, Israth Jahan, Monty, Masuma Akter, Luo, Shenggen, Shao, Jiaqi, Yan, Zhiqiang, Yu, Lei
• Format: Journal Article
• Language: English
• Published: United States 01.10.2020
• Subjects: antibody fragments; HCC; gene therapy; immune microenvironment; IL-17A

High interleukin 17A (IL-17A) expression in hepatocellular carcinoma (HCC) tissue promotes HCC development. This study explores a method to inhibit HCC growth by neutralizing IL-17A in the HCC microenvironment. A novel type 5 adenoviral vector (Ad5) that carries DNA sequences encoding specific neutr...