Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration

• Published in: Journal of Alzheimer's disease Vol. 52; no. 1; p. 179
• Main Authors: Wang, Hui-Fu, Wan, Yu, Hao, Xiao-Ke, Cao, Lei, Zhu, Xi-Chen, Jiang, Teng, Tan, Meng-Shan, Tan, Lin, Zhang, Dao-Qiang, Tan, Lan, Yu, Jin-Tai
• Format: Journal Article
• Language: English
• Published: Netherlands 26.04.2016
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - metabolism; Brain - diagnostic imaging; Brain - metabolism; Databases, Factual; European Continental Ancestry Group - genetics; Female; Follow-Up Studies; Genetic Predisposition to Disease; Glucose - metabolism; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Degeneration - diagnostic imaging; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Risk; tau Proteins - cerebrospinal fluid; Tumor Suppressor Proteins - genetics; Aβ deposition; Alzheimer’s disease; BIN1; brain structure; glucose metabolism; cerebrospinal fluid

Bridging integrator 1 (BIN1) has been identified as one of the most associated loci for Alzheimer's disease (AD), and recently was reported to modulate tau pathology to mediate AD in vitro. However, the effects of BIN1 on the AD related biomarkers in AD continuum were not specifically assessed....