Silencing and Nuclear Repositioning of the λ5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1

• Published in: PloS one Vol. 3; no. 10; p. e3568
• Main Authors: Karnowski, Alexander, Cao, Chun, Matthias, Gabriele, Carotta, Sebastian, Corcoran, Lynn M., Martensson, Inga-Lill, Skok, Jane A., Matthias, Patrick
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 30.10.2008
• Subjects: Biomedical research; Bone marrow; Cell activation; Cell cycle; Chains; Chromatin; Deoxyribonucleic acid; Deregulation; DNA; Fibroblasts; Gene expression; Genes; Genetics and Genomics/Gene Expression; Genetics and Genomics/Gene Function; Immunoglobulins; Immunology; Immunology/Genetics of the Immune System; Immunology/Leukocyte Development; Immunology/Leukocyte Signaling and Gene Expression; Laboratories; Light; Lymphocytes; Lymphocytes B; Medical research; Mice; Proteins; Rodents; Spleen; Transcription; Transcription factors; New York; United States > US; Switzerland

The chromatin regulator Aiolos and the transcriptional coactivator OBF-1 have been implicated in regulating aspects of B cell maturation and activation. Mice lacking either of these factors have a largely normal early B cell development. However, when both factors are eliminated simultaneously a blo...