Contribution of Bone Marrow–Derived Mesenchymal Stem Cells to Healing of Pulmonary Contusion-Created Rats

The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats. A total of 45 male Wistar al...

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Published in	The Journal of surgical research Vol. 261; pp. 205 - 214
Main Authors	Demir, Sabri, Erturk, Ahmet, Gunal, Yasemin Dere, Ozmen, Ismail, Zengin, Mehmet, Yildiz, Dincer, Karaoz, Erdal, Karahan, Siyami, Senel, Emrah
Format	Journal Article
Language	English
Published	United States Elsevier Inc 01.05.2021
Subjects	Acute Lung Injury - pathology Acute Lung Injury - therapy Animals Bone Marrow Transplantation Bone marrow-derived mesenchymal stem cells Cells, Cultured Children Contusions - therapy Lung - pathology Male Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Microscopy, Fluorescence Pulmonary contusion Rats Rats, Wistar Thoracic injury Trauma Wound Healing Thoracic injury Bone marrow-derived mesenchymal stem cells Children Pulmonary contusion Trauma
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Abstract	The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats. A total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant. BM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II. The greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods.
AbstractList	The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats. A total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant. BM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II. The greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods. The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats.BACKGROUNDThe most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study aims to examine the effects of BM-MSCs on PC healing in rats.A total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant.MATERIALS AND METHODSA total of 45 male Wistar albino rats were used. Four groups were formed. BM-MSCs were labeled with the green fluorescent protein. PC was observed in the control group. In group II, PC occured and left to spontaneous healing. In group III, PC formed and BM-MSCs were given. In group IV, BM-MSCs were given without PC formation. Subjects were sacrificed 1 week later. Whether there was any difference in terms of BM-MSC involvement and lung injury score was investigated. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS), version 17.0, software (SPSS Inc., Chicago, IL), and p value of <0.05 was considered statistically significant.BM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II.RESULTSBM-MSCs were collected much more in the lungs in group III than in group IV. Group III had a lower lung injury score value than group II.The greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods.CONCLUSIONThe greater involvement of the BM-MSCs in the injury site, and further reductions in lung injury score suggest that BM-MSCs are contributing to the healing of the injury. The use of BM-MSCs in risky patients with diffuse PC may be an alternative treatment to conventional methods.
Author	Demir, Sabri Zengin, Mehmet Gunal, Yasemin Dere Karahan, Siyami Karaoz, Erdal Senel, Emrah Yildiz, Dincer Erturk, Ahmet Ozmen, Ismail
Author_xml	– sequence: 1 givenname: Sabri orcidid: 0000-0003-4720-912X surname: Demir fullname: Demir, Sabri email: drsabridemir@gmail.com organization: Department of Pediatric Surgery, Ankara Bilkent City Hospital, Children Hospital, Ankara, Turkey – sequence: 2 givenname: Ahmet orcidid: 0000-0003-0286-362X surname: Erturk fullname: Erturk, Ahmet organization: Department of Pediatric Surgery, Ankara Bilkent City Hospital, Children Hospital, Ankara, Turkey – sequence: 3 givenname: Yasemin Dere surname: Gunal fullname: Gunal, Yasemin Dere organization: Department of Pediatric Surgery, School of Medicine, Kirikkale University, Kirikkale, Turkey – sequence: 4 givenname: Ismail surname: Ozmen fullname: Ozmen, Ismail organization: Department of Pediatric Surgery, School of Medicine, Kirikkale University, Kirikkale, Turkey – sequence: 5 givenname: Mehmet surname: Zengin fullname: Zengin, Mehmet organization: Department of Pathology, School of Medicine, Kirikkale University, Kirikkale, Turkey – sequence: 6 givenname: Dincer surname: Yildiz fullname: Yildiz, Dincer organization: Faculty of Veterinary, Department of Anatomy, Kirikkale University, Kirikkale, Turkey – sequence: 7 givenname: Erdal surname: Karaoz fullname: Karaoz, Erdal organization: Department of Histology and Embryology, School of Medicine, Istinye University, İstanbul, Turkey – sequence: 8 givenname: Siyami surname: Karahan fullname: Karahan, Siyami organization: Faculty of Veterinary, Department of Histology, Kirikkale University, Kirikkale, Turkey – sequence: 9 givenname: Emrah surname: Senel fullname: Senel, Emrah organization: Department of Pediatric Surgery, School of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Turkey
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CitedBy_id	crossref_primary_10_1016_j_prp_2023_154332 crossref_primary_10_24938_kutfd_885552 crossref_primary_10_3389_fphar_2022_1098634 crossref_primary_10_1155_2022_4579030
Cites_doi	10.1097/PCC.0b013e3181a63f58 10.1089/scd.2010.0125 10.1002/sctm.20-0146 10.1016/j.imlet.2015.06.019 10.1097/00007611-199812000-00002 10.1016/j.cellimm.2016.08.008 10.1634/stemcells.2006-0164 10.1097/00007611-199605000-00009 10.1213/01.ANE.0000180201.25746.1F 10.1016/j.surg.2015.12.006 10.1186/s13287-020-01875-5 10.1016/S0140-6736(08)60690-X 10.1016/j.yexcr.2014.03.013 10.1016/j.transproceed.2006.02.053 10.1097/TA.0000000000000592 10.1016/j.jcyt.2013.01.005 10.1016/j.surg.2014.07.001 10.1007/s00383-004-1165-z 10.1182/blood-2003-05-1670 10.1016/S0022-3476(05)81534-3 10.1007/s12015-011-9292-0 10.1097/01.sla.0000094441.38807.09 10.1007/s00167-006-0124-8 10.1186/s13287-015-0034-0 10.1016/0022-3468(90)90238-5 10.1186/1742-2094-9-228 10.1038/nm1391 10.1016/j.surg.2012.06.020 10.1542/peds.2008-0094 10.1016/j.diff.2016.04.001 10.1002/sctm.19-0205 10.1016/j.rcl.2011.06.002 10.2144/fsoa-2020-0048 10.1016/j.injury.2010.09.010 10.1007/s00418-009-0629-6 10.1097/00005373-199109000-00002
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Keywords	Thoracic injury Bone marrow-derived mesenchymal stem cells Children Pulmonary contusion Trauma
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References	Karaoz, Aksoy, Ayhan, Sariboyaci, Kaymaz, Kasap (bib20) 2009; 132 Peng, Sun, Sheng (bib19) 2015; 6 Gore, Bible, Livingston, Mohr, Sifri (bib25) 2016; 159 Allen, Cox (bib7) 1998; 91 Abraham, Krasnodembskaya (bib27) 2020; 9 Gore, Bible, Livingston, Mohr, Sifri (bib24) 2015; 78 Hong, Zhang, Sultana, Yu, Wei (bib39) 2011; 20 (bib1) 2008; 121 Qu, Wang, Hare (bib31) 2020; 9 Yoon, Mansukhani, Stubbs, Helenowski, Woodruff, Kibbe (bib37) 2014; 156 Amital, Shitrit, Fox (bib34) 2009; 11 Davis, Furman, Costarino (bib33) 1993; 123 Black, Snyder, Miller, Mann, Copetas, Ellis (bib2) 1996; 89 Yan, Zhuansun, Chen, Li, Ran (bib26) 2014; 324 Chen, Hu, Chen (bib28) 2020; 6 Lee, Kuo, Chen, Lee, Hsieh, Chen (bib10) 2004; 103 Walker, Bedi, Shah (bib12) 2012; 9 Badami, Livingston, Sifri (bib14) 2007; 63 Peclet, Newman, Eichelberger, Gotschall, Garcia, Bowman (bib4) 1990; 25 Shah, Ulm, Sifri, Mohr, Livingston (bib15) 2009; 67 Freitag, Wickham, Shah, Tenen (bib30) 2020; 6 Cornelissen, Maijenburg, Nolte, Voermans (bib9) 2015; 168 Karaoz, Okcu, Unal, Subasi, Saglam, Duruksu (bib22) 2013; 15 Hannoush, Elhassan, Sifri, Mohr, Alzate, Livingston (bib36) 2013; 153 Moore, Wallace, Westra (bib3) 2011; 49 Le Blanc, Frassoni, Ball (bib13) 2008; 371 Giannoudis, Goff, Roshdy, Jones, McGonagle (bib8) 2010; 41 Agung, Ochi, Yanada (bib32) 2006; 14 Livingston, Anjaria, Wu (bib16) 2003; 238 Niada, Giannasi, Ferreira, Milani, Arrigoni, Brini (bib40) 2016; 92 Rochefort, Delorme, Lopez (bib17) 2006; 24 Kishikawa, Yoshioka, Shimazu, Sugimoto, Yoshioka, Sugimoto (bib35) 1991; 31 Ozdemir, Ozgul Ozdemir, Kirmaz (bib21) 2016; 310 Ayaloglu-Butun, Terzioglu-Kara, Tokcaer-Keskin, Akcali (bib38) 2012; 8 Haxhija, Nores, Schober, Hollwarth (bib5) 2004; 20 Wylie, Morrison, Nalk (bib6) 2009; 10 Raghavendran, Davidson, Helinski (bib23) 2005; 101 Shu, Niu, Li (bib29) 2020; 11 Mansilla, Marin, Drago (bib18) 2006; 38 Miyahara, Nagaya, Kataoka (bib11) 2006; 12 Karaoz (10.1016/j.jss.2020.12.006_bib20) 2009; 132 (10.1016/j.jss.2020.12.006_bib1) 2008; 121 Badami (10.1016/j.jss.2020.12.006_bib14) 2007; 63 Rochefort (10.1016/j.jss.2020.12.006_bib17) 2006; 24 Allen (10.1016/j.jss.2020.12.006_bib7) 1998; 91 Ozdemir (10.1016/j.jss.2020.12.006_bib21) 2016; 310 Amital (10.1016/j.jss.2020.12.006_bib34) 2009; 11 Hong (10.1016/j.jss.2020.12.006_bib39) 2011; 20 Freitag (10.1016/j.jss.2020.12.006_bib30) 2020; 6 Chen (10.1016/j.jss.2020.12.006_bib28) 2020; 6 Yoon (10.1016/j.jss.2020.12.006_bib37) 2014; 156 Davis (10.1016/j.jss.2020.12.006_bib33) 1993; 123 Gore (10.1016/j.jss.2020.12.006_bib24) 2015; 78 Black (10.1016/j.jss.2020.12.006_bib2) 1996; 89 Niada (10.1016/j.jss.2020.12.006_bib40) 2016; 92 Wylie (10.1016/j.jss.2020.12.006_bib6) 2009; 10 Peng (10.1016/j.jss.2020.12.006_bib19) 2015; 6 Walker (10.1016/j.jss.2020.12.006_bib12) 2012; 9 Mansilla (10.1016/j.jss.2020.12.006_bib18) 2006; 38 Agung (10.1016/j.jss.2020.12.006_bib32) 2006; 14 Gore (10.1016/j.jss.2020.12.006_bib25) 2016; 159 Cornelissen (10.1016/j.jss.2020.12.006_bib9) 2015; 168 Shu (10.1016/j.jss.2020.12.006_bib29) 2020; 11 Ayaloglu-Butun (10.1016/j.jss.2020.12.006_bib38) 2012; 8 Kishikawa (10.1016/j.jss.2020.12.006_bib35) 1991; 31 Giannoudis (10.1016/j.jss.2020.12.006_bib8) 2010; 41 Raghavendran (10.1016/j.jss.2020.12.006_bib23) 2005; 101 Yan (10.1016/j.jss.2020.12.006_bib26) 2014; 324 Qu (10.1016/j.jss.2020.12.006_bib31) 2020; 9 Lee (10.1016/j.jss.2020.12.006_bib10) 2004; 103 Hannoush (10.1016/j.jss.2020.12.006_bib36) 2013; 153 Le Blanc (10.1016/j.jss.2020.12.006_bib13) 2008; 371 Shah (10.1016/j.jss.2020.12.006_bib15) 2009; 67 Livingston (10.1016/j.jss.2020.12.006_bib16) 2003; 238 Karaoz (10.1016/j.jss.2020.12.006_bib22) 2013; 15 Haxhija (10.1016/j.jss.2020.12.006_bib5) 2004; 20 Abraham (10.1016/j.jss.2020.12.006_bib27) 2020; 9 Moore (10.1016/j.jss.2020.12.006_bib3) 2011; 49 Peclet (10.1016/j.jss.2020.12.006_bib4) 1990; 25 Miyahara (10.1016/j.jss.2020.12.006_bib11) 2006; 12
References_xml	– volume: 159 start-page: 1430 year: 2016 end-page: 1435 ident: bib25 article-title: Mesenchymal stem cells enhance lung recovery after injury, shock, and chronic stress publication-title: Surgery – volume: 31 start-page: 1203 year: 1991 end-page: 1208 ident: bib35 article-title: Pulmonary contusion causes long-term respiratory dysfunction with decreased functional residual capacity publication-title: J Trauma – volume: 9 start-page: 1007 year: 2020 end-page: 1022 ident: bib31 article-title: Cell-based therapy to reduce mortality from COVID-19: systematic review and meta-analysis of human studies on acute respiratory distress syndrome publication-title: Stem Cells Transl Med – volume: 63 start-page: 596 year: 2007 end-page: 600 ident: bib14 article-title: Hematopoietic progenitor cells mobilize to the site of injury after trauma and hemorrhagic shock in rats publication-title: J Trauma – volume: 6 start-page: FSO584 year: 2020 ident: bib30 article-title: Mesenchymal stem cell use in acute respiratory distress syndrome: a potential therapeutic application publication-title: Future Sci OA – volume: 11 start-page: 673 year: 2009 end-page: 676 ident: bib34 article-title: Long-term pulmonary function after recovery from pulmonary contusion due to blunt chest trauma publication-title: Isr Med Assoc J – volume: 6 start-page: 47 year: 2015 ident: bib19 article-title: Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury publication-title: Stem Cell Res Ther – volume: 78 start-page: 767 year: 2015 end-page: 772 ident: bib24 article-title: Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury? publication-title: J Trauma Acute Care Surg – volume: 20 start-page: 925 year: 2011 end-page: 931 ident: bib39 article-title: The effects of 17-beta estradiol on enhancing proliferation of human bone marrow mesenchymal stromal cells in vitro publication-title: Stem Cells Dev – volume: 92 start-page: 291 year: 2016 end-page: 297 ident: bib40 article-title: 17beta-estradiol differently affects osteogenic differentiation of mesenchymal stem/stromal cells from adipose tissue and bone marrow publication-title: Differentiation – volume: 11 start-page: 361 year: 2020 ident: bib29 article-title: Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells publication-title: Stem Cell Res Ther – volume: 9 start-page: 228 year: 2012 ident: bib12 article-title: Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population publication-title: J Neuroinflammation – volume: 41 start-page: 1099 year: 2010 end-page: 1102 ident: bib8 article-title: Does mobilisation and transmigration of mesenchymal stem cells occur after trauma? publication-title: Injury – volume: 89 start-page: 494 year: 1996 end-page: 496 ident: bib2 article-title: Significance of chest trauma in children publication-title: South Med J – volume: 310 start-page: 108 year: 2016 end-page: 115 ident: bib21 article-title: The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets publication-title: Cell Immunol – volume: 132 start-page: 533 year: 2009 end-page: 546 ident: bib20 article-title: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers publication-title: Histochem Cell Biol – volume: 25 start-page: 961 year: 1990 end-page: 965 ident: bib4 article-title: Thoracic trauma in children: an indicator of increased mortality publication-title: J Pediatr Surg – volume: 153 start-page: 44 year: 2013 end-page: 51 ident: bib36 article-title: Role of bone marrow and mesenchymal stem cells in healing after traumatic injury publication-title: Surgery – volume: 91 start-page: 1099 year: 1998 end-page: 1106 ident: bib7 article-title: Pulmonary contusion in children: diagnosis and management publication-title: South Med J – volume: 20 start-page: 412 year: 2004 end-page: 414 ident: bib5 article-title: Lung contusion-lacerations after blunt thoracic trauma in children publication-title: Pediatr Surg Int – volume: 38 start-page: 967 year: 2006 end-page: 969 ident: bib18 article-title: Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine publication-title: Transplant Proc – volume: 8 start-page: 393 year: 2012 end-page: 401 ident: bib38 article-title: The effect of estrogen on bone marrow-derived rat mesenchymal stem cell maintenance: inhibiting apoptosis through the expression of Bcl-xL and Bcl-2 publication-title: Stem Cell Rev Rep – volume: 14 start-page: 1307 year: 2006 end-page: 1314 ident: bib32 article-title: Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration publication-title: Knee Surg Sports Traumatol Arthrosc – volume: 10 start-page: 643 year: 2009 end-page: 647 ident: bib6 article-title: Lung contusion in children–early computed tomography versus radiography publication-title: Pediatr Crit Care Med – volume: 24 start-page: 2202 year: 2006 end-page: 2208 ident: bib17 article-title: Multipotential mesenchymal stem cells are mobilized into peripheral blood by hypoxia publication-title: Stem Cells – volume: 49 start-page: 949 year: 2011 end-page: 968 ident: bib3 article-title: Chest trauma in children: current imaging guidelines and techniques publication-title: Radiol Clin North Am – volume: 168 start-page: 159 year: 2015 end-page: 169 ident: bib9 article-title: Organ-specific migration of mesenchymal stromal cells: who, when, where and why? publication-title: Immunol Lett – volume: 156 start-page: 508 year: 2014 end-page: 516 ident: bib37 article-title: Sex bias exists in basic science and translational surgical research publication-title: Surgery – volume: 238 start-page: 748 year: 2003 end-page: 753 ident: bib16 article-title: Bone marrow failure following severe injury in humans publication-title: Ann Surg – volume: 103 start-page: 1669 year: 2004 end-page: 1675 ident: bib10 article-title: Isolation of multipotent mesenchymal stem cells from umbilical cord blood publication-title: Blood – volume: 121 start-page: 849 year: 2008 end-page: 854 ident: bib1 article-title: Management of pediatric trauma publication-title: Pediatrics – volume: 101 start-page: 1482 year: 2005 end-page: 1489 ident: bib23 article-title: A rat model for isolated bilateral lung contusion from blunt chest trauma publication-title: Anesth Analg – volume: 123 start-page: 35 year: 1993 end-page: 45 ident: bib33 article-title: Adult respiratory distress syndrome in children: associated disease, clinical course, and predictors of death publication-title: J Pediatr – volume: 9 start-page: 28 year: 2020 end-page: 38 ident: bib27 article-title: Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome publication-title: Stem Cells Transl Med – volume: 371 start-page: 1579 year: 2008 end-page: 1586 ident: bib13 article-title: Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study publication-title: Lancet – volume: 6 start-page: 1153 year: 2020 end-page: 1161 ident: bib28 article-title: Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment publication-title: Engineering (Beijing) – volume: 15 start-page: 557 year: 2013 end-page: 570 ident: bib22 article-title: Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulin-producing cells in pancreatic islet microenvironment both in vitro and in vivo publication-title: Cytotherapy – volume: 12 start-page: 459 year: 2006 end-page: 465 ident: bib11 article-title: Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction publication-title: Nat Med – volume: 67 start-page: 315 year: 2009 end-page: 321 ident: bib15 article-title: Mobilization of bone marrow cells to the site of injury is necessary for wound healing publication-title: J Trauma – volume: 324 start-page: 65 year: 2014 end-page: 74 ident: bib26 article-title: Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism publication-title: Exp Cell Res – volume: 10 start-page: 643 year: 2009 ident: 10.1016/j.jss.2020.12.006_bib6 article-title: Lung contusion in children–early computed tomography versus radiography publication-title: Pediatr Crit Care Med doi: 10.1097/PCC.0b013e3181a63f58 – volume: 20 start-page: 925 year: 2011 ident: 10.1016/j.jss.2020.12.006_bib39 article-title: The effects of 17-beta estradiol on enhancing proliferation of human bone marrow mesenchymal stromal cells in vitro publication-title: Stem Cells Dev doi: 10.1089/scd.2010.0125 – volume: 9 start-page: 1007 year: 2020 ident: 10.1016/j.jss.2020.12.006_bib31 article-title: Cell-based therapy to reduce mortality from COVID-19: systematic review and meta-analysis of human studies on acute respiratory distress syndrome publication-title: Stem Cells Transl Med doi: 10.1002/sctm.20-0146 – volume: 168 start-page: 159 year: 2015 ident: 10.1016/j.jss.2020.12.006_bib9 article-title: Organ-specific migration of mesenchymal stromal cells: who, when, where and why? publication-title: Immunol Lett doi: 10.1016/j.imlet.2015.06.019 – volume: 91 start-page: 1099 year: 1998 ident: 10.1016/j.jss.2020.12.006_bib7 article-title: Pulmonary contusion in children: diagnosis and management publication-title: South Med J doi: 10.1097/00007611-199812000-00002 – volume: 310 start-page: 108 year: 2016 ident: 10.1016/j.jss.2020.12.006_bib21 article-title: The paracrine immunomodulatory interactions between the human dental pulp derived mesenchymal stem cells and CD4 T cell subsets publication-title: Cell Immunol doi: 10.1016/j.cellimm.2016.08.008 – volume: 24 start-page: 2202 year: 2006 ident: 10.1016/j.jss.2020.12.006_bib17 article-title: Multipotential mesenchymal stem cells are mobilized into peripheral blood by hypoxia publication-title: Stem Cells doi: 10.1634/stemcells.2006-0164 – volume: 89 start-page: 494 year: 1996 ident: 10.1016/j.jss.2020.12.006_bib2 article-title: Significance of chest trauma in children publication-title: South Med J doi: 10.1097/00007611-199605000-00009 – volume: 101 start-page: 1482 year: 2005 ident: 10.1016/j.jss.2020.12.006_bib23 article-title: A rat model for isolated bilateral lung contusion from blunt chest trauma publication-title: Anesth Analg doi: 10.1213/01.ANE.0000180201.25746.1F – volume: 11 start-page: 673 year: 2009 ident: 10.1016/j.jss.2020.12.006_bib34 article-title: Long-term pulmonary function after recovery from pulmonary contusion due to blunt chest trauma publication-title: Isr Med Assoc J – volume: 63 start-page: 596 year: 2007 ident: 10.1016/j.jss.2020.12.006_bib14 article-title: Hematopoietic progenitor cells mobilize to the site of injury after trauma and hemorrhagic shock in rats publication-title: J Trauma – volume: 159 start-page: 1430 year: 2016 ident: 10.1016/j.jss.2020.12.006_bib25 article-title: Mesenchymal stem cells enhance lung recovery after injury, shock, and chronic stress publication-title: Surgery doi: 10.1016/j.surg.2015.12.006 – volume: 11 start-page: 361 year: 2020 ident: 10.1016/j.jss.2020.12.006_bib29 article-title: Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells publication-title: Stem Cell Res Ther doi: 10.1186/s13287-020-01875-5 – volume: 371 start-page: 1579 year: 2008 ident: 10.1016/j.jss.2020.12.006_bib13 article-title: Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study publication-title: Lancet doi: 10.1016/S0140-6736(08)60690-X – volume: 324 start-page: 65 year: 2014 ident: 10.1016/j.jss.2020.12.006_bib26 article-title: Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2014.03.013 – volume: 38 start-page: 967 year: 2006 ident: 10.1016/j.jss.2020.12.006_bib18 article-title: Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine publication-title: Transplant Proc doi: 10.1016/j.transproceed.2006.02.053 – volume: 78 start-page: 767 year: 2015 ident: 10.1016/j.jss.2020.12.006_bib24 article-title: Can mesenchymal stem cells reverse chronic stress-induced impairment of lung healing following traumatic injury? publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0000000000000592 – volume: 15 start-page: 557 year: 2013 ident: 10.1016/j.jss.2020.12.006_bib22 article-title: Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulin-producing cells in pancreatic islet microenvironment both in vitro and in vivo publication-title: Cytotherapy doi: 10.1016/j.jcyt.2013.01.005 – volume: 156 start-page: 508 year: 2014 ident: 10.1016/j.jss.2020.12.006_bib37 article-title: Sex bias exists in basic science and translational surgical research publication-title: Surgery doi: 10.1016/j.surg.2014.07.001 – volume: 20 start-page: 412 year: 2004 ident: 10.1016/j.jss.2020.12.006_bib5 article-title: Lung contusion-lacerations after blunt thoracic trauma in children publication-title: Pediatr Surg Int doi: 10.1007/s00383-004-1165-z – volume: 67 start-page: 315 year: 2009 ident: 10.1016/j.jss.2020.12.006_bib15 article-title: Mobilization of bone marrow cells to the site of injury is necessary for wound healing publication-title: J Trauma – volume: 103 start-page: 1669 year: 2004 ident: 10.1016/j.jss.2020.12.006_bib10 article-title: Isolation of multipotent mesenchymal stem cells from umbilical cord blood publication-title: Blood doi: 10.1182/blood-2003-05-1670 – volume: 123 start-page: 35 year: 1993 ident: 10.1016/j.jss.2020.12.006_bib33 article-title: Adult respiratory distress syndrome in children: associated disease, clinical course, and predictors of death publication-title: J Pediatr doi: 10.1016/S0022-3476(05)81534-3 – volume: 6 start-page: 1153 year: 2020 ident: 10.1016/j.jss.2020.12.006_bib28 article-title: Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment publication-title: Engineering (Beijing) – volume: 8 start-page: 393 year: 2012 ident: 10.1016/j.jss.2020.12.006_bib38 article-title: The effect of estrogen on bone marrow-derived rat mesenchymal stem cell maintenance: inhibiting apoptosis through the expression of Bcl-xL and Bcl-2 publication-title: Stem Cell Rev Rep doi: 10.1007/s12015-011-9292-0 – volume: 238 start-page: 748 year: 2003 ident: 10.1016/j.jss.2020.12.006_bib16 article-title: Bone marrow failure following severe injury in humans publication-title: Ann Surg doi: 10.1097/01.sla.0000094441.38807.09 – volume: 14 start-page: 1307 year: 2006 ident: 10.1016/j.jss.2020.12.006_bib32 article-title: Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration publication-title: Knee Surg Sports Traumatol Arthrosc doi: 10.1007/s00167-006-0124-8 – volume: 6 start-page: 47 year: 2015 ident: 10.1016/j.jss.2020.12.006_bib19 article-title: Systematic review and meta-analysis of efficacy of mesenchymal stem cells on locomotor recovery in animal models of traumatic brain injury publication-title: Stem Cell Res Ther doi: 10.1186/s13287-015-0034-0 – volume: 25 start-page: 961 year: 1990 ident: 10.1016/j.jss.2020.12.006_bib4 article-title: Thoracic trauma in children: an indicator of increased mortality publication-title: J Pediatr Surg doi: 10.1016/0022-3468(90)90238-5 – volume: 9 start-page: 228 year: 2012 ident: 10.1016/j.jss.2020.12.006_bib12 article-title: Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population publication-title: J Neuroinflammation doi: 10.1186/1742-2094-9-228 – volume: 12 start-page: 459 year: 2006 ident: 10.1016/j.jss.2020.12.006_bib11 article-title: Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction publication-title: Nat Med doi: 10.1038/nm1391 – volume: 153 start-page: 44 year: 2013 ident: 10.1016/j.jss.2020.12.006_bib36 article-title: Role of bone marrow and mesenchymal stem cells in healing after traumatic injury publication-title: Surgery doi: 10.1016/j.surg.2012.06.020 – volume: 121 start-page: 849 year: 2008 ident: 10.1016/j.jss.2020.12.006_bib1 article-title: Management of pediatric trauma publication-title: Pediatrics doi: 10.1542/peds.2008-0094 – volume: 92 start-page: 291 year: 2016 ident: 10.1016/j.jss.2020.12.006_bib40 article-title: 17beta-estradiol differently affects osteogenic differentiation of mesenchymal stem/stromal cells from adipose tissue and bone marrow publication-title: Differentiation doi: 10.1016/j.diff.2016.04.001 – volume: 9 start-page: 28 year: 2020 ident: 10.1016/j.jss.2020.12.006_bib27 article-title: Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome publication-title: Stem Cells Transl Med doi: 10.1002/sctm.19-0205 – volume: 49 start-page: 949 year: 2011 ident: 10.1016/j.jss.2020.12.006_bib3 article-title: Chest trauma in children: current imaging guidelines and techniques publication-title: Radiol Clin North Am doi: 10.1016/j.rcl.2011.06.002 – volume: 6 start-page: FSO584 year: 2020 ident: 10.1016/j.jss.2020.12.006_bib30 article-title: Mesenchymal stem cell use in acute respiratory distress syndrome: a potential therapeutic application publication-title: Future Sci OA doi: 10.2144/fsoa-2020-0048 – volume: 41 start-page: 1099 year: 2010 ident: 10.1016/j.jss.2020.12.006_bib8 article-title: Does mobilisation and transmigration of mesenchymal stem cells occur after trauma? publication-title: Injury doi: 10.1016/j.injury.2010.09.010 – volume: 132 start-page: 533 year: 2009 ident: 10.1016/j.jss.2020.12.006_bib20 article-title: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers publication-title: Histochem Cell Biol doi: 10.1007/s00418-009-0629-6 – volume: 31 start-page: 1203 year: 1991 ident: 10.1016/j.jss.2020.12.006_bib35 article-title: Pulmonary contusion causes long-term respiratory dysfunction with decreased functional residual capacity publication-title: J Trauma doi: 10.1097/00005373-199109000-00002
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Snippet	The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in... The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are used in...
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SubjectTerms	Acute Lung Injury - pathology Acute Lung Injury - therapy Animals Bone Marrow Transplantation Bone marrow-derived mesenchymal stem cells Cells, Cultured Children Contusions - therapy Lung - pathology Male Mesenchymal Stem Cell Transplantation Mesenchymal Stem Cells - cytology Microscopy, Fluorescence Pulmonary contusion Rats Rats, Wistar Thoracic injury Trauma Wound Healing
Title	Contribution of Bone Marrow–Derived Mesenchymal Stem Cells to Healing of Pulmonary Contusion-Created Rats
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