The ovulation assessment of regular cyclic rats following subacute oral administration of monosodium glutamate: An in vivo study

Context: The possible toxic effects of monosodium glutamate (MSG) on ovarian functions have not been thoroughly evaluated in contrast to testicular functions. Few studies documented that MSG showed histological alterations. Aims: To investigate the subacute effects of oral MSG (2 g/kg) on estrogen l...

Full description

Saved in:
Bibliographic Details
Published inJournal of pharmacy & pharmacognosy research Vol. 10; no. 3; pp. 397 - 405
Main Author Abdulghani, Mahfoudh Almusli Mohammed
Format Journal Article
LanguageEnglish
Published GarVal Editorial Ltda 01.05.2022
Subjects
corpora lutea
estrogen level
follicles ovarian
monosodium glutamate
oocytes
ovulation
toxicity
Online AccessGet full text

Cover

More Information
Summary:Context: The possible toxic effects of monosodium glutamate (MSG) on ovarian functions have not been thoroughly evaluated in contrast to testicular functions. Few studies documented that MSG showed histological alterations. Aims: To investigate the subacute effects of oral MSG (2 g/kg) on estrogen level and numbers of ovulated oocytes and histological changes in ovary of Sprague-Dawley (SD) rats. Methods: Virgin young adult SD female rats with a regular estrous cycle were randomly assigned to either MSG-treated group or control group, and the duration of treatment was 14-16 days for oral administration MSG or vehicle (distilled water), respectively. Results: Oral MSG treatment with doses of 2 g/kg/day showed significantly (p<0.01) reduced numbers of ovulated oocytes in the oviduct, newly formed corpora lutea, large follicles in histology of ovarian sections and attenuated serum estrogen levels. Conclusions: Subacute oral administration of MSG may negatively influence the ovarian function of young female rats via reduction of ovulated oocytes and the attenuation of estrogen level.
ISSN:0719-4250
0719-4250
DOI:10.56499/jppres21.1312_10.3.397