Experimental induction of rhabdomyosarcoma in mice with fractionated doses of β-irradiation

• Published in: Journal of cancer research and clinical oncology Vol. 125; no. 5; pp. 257 - 267
• Main Authors: GUPTA, A, ANDREWS, K. L, MCDANIEL, K. M, NAGLE, R. B, BOWDEN, G. T
• Format: Journal Article
• Language: English
• Published: Berlin Springer 1999
• Subjects: Animal tumors. Experimental tumors; Animals; Beta Particles - adverse effects; Biological and medical sciences; Carcinoma, Squamous Cell - etiology; Desmin - analysis; Disease Models, Animal; Dose Fractionation, Radiation; Experimental bone, joint and muscle tumors; Gene Expression Regulation, Neoplastic; Histiocytoma, Benign Fibrous - etiology; Immunohistochemistry; Medical sciences; Mice; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma - chemistry; Rhabdomyosarcoma - etiology; Rhabdomyosarcoma - pathology; Skin Neoplasms - chemistry; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Tumors; Animal model; Sarcoma; Tumoral tissue; Rodentia; Rhabdomyosarcoma; Malignant tumor; Cell line establishment; Fractionated dose; Striated muscle disease; Vertebrata; Mammalia; Beta irradiation; Mouse; Animal; Established cell line; Tumor progression; Tumor cell

Repeated doses of beta-radiation in the mouse skin model have been reported to produce carcinomas and sarcomas with equal frequency. Among sarcomas, fibrosarcomas and osteosarcomas have been the predominant reported histologies. In this report we describe the beta-radiation induction of rhabdomyosar...