A proposed method for in vivo determination of lithium in human brain

A method for measuring Li in vivo in human brain is presented. The technique is based on the measurement of tritium gas exhaled by the subject following neutron irradiation of the organ of interest. The gas collection facility used to separate minute amounts of tritium from the breath is described....

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Published inPhysics in medicine & biology Vol. 30; no. 11; pp. 1225 - 1236
Main Authors Vartsky, D, LoMonte, A, Ellis, K J, Yasumura, S, Cohn, S H
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.11.1985
Institute of Physics
Subjects
Air - analysis
Animals
Biological and medical sciences
Brain Chemistry
Chlorides
Humans
Investigative techniques, diagnostic techniques (general aspects)
Isotopes
Lithium - analysis
Lithium Chloride
Medical sciences
Radioisotope Dilution Technique
Rats
Respiration
Tritium
Expired gas
Human
In vivo
Detection limit
Central nervous system
Lithium
Tritium
Concentration
Measurement method
Liquid scintillation
Online AccessGet full text
ISSN0031-9155
1361-6560
DOI10.1088/0031-9155/30/11/005

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Abstract A method for measuring Li in vivo in human brain is presented. The technique is based on the measurement of tritium gas exhaled by the subject following neutron irradiation of the organ of interest. The gas collection facility used to separate minute amounts of tritium from the breath is described. Methods for reducing the background levels of tritium were investigated. The limit of detection of the system is estimated to be 350 micrograms of Li for the whole brain for a dose of 10 mSv. This detection limit is sufficient for the study of patients treated with lithium compounds, but is too high to study 'normal' brain lithium content. The rate of elimination of tritium gas from the body was also investigated in animal studies. The method also appears suitable for the measurement of lithium levels in the kidney.
AbstractList A method for measuring Li in vivo in human brain is presented. The technique is based on the measurement of tritium gas exhaled by the subject following neutron irradiation of the organ of interest. The gas collection facility used to separate minute amounts of tritium from the breath is described. Methods for reducing the background levels of tritium were investigated. The limit of detection of the system is estimated to be 350 micrograms of Li for the whole brain for a dose of 10 mSv. This detection limit is sufficient for the study of patients treated with lithium compounds, but is too high to study 'normal' brain lithium content. The rate of elimination of tritium gas from the body was also investigated in animal studies. The method also appears suitable for the measurement of lithium levels in the kidney.A method for measuring Li in vivo in human brain is presented. The technique is based on the measurement of tritium gas exhaled by the subject following neutron irradiation of the organ of interest. The gas collection facility used to separate minute amounts of tritium from the breath is described. Methods for reducing the background levels of tritium were investigated. The limit of detection of the system is estimated to be 350 micrograms of Li for the whole brain for a dose of 10 mSv. This detection limit is sufficient for the study of patients treated with lithium compounds, but is too high to study 'normal' brain lithium content. The rate of elimination of tritium gas from the body was also investigated in animal studies. The method also appears suitable for the measurement of lithium levels in the kidney.
A method for measuring Li in vivo in human brain is presented. The technique is based on the measurement of tritium gas exhaled by the subject following neutron irradiation of the organ of interest. The gas collection facility used to separate minute amounts of tritium from the breath is described. Methods for reducing the background levels of tritium were investigated. The limit of detection of the system is estimated to be 350 micrograms of Li for the whole brain for a dose of 10 mSv. This detection limit is sufficient for the study of patients treated with lithium compounds, but is too high to study 'normal' brain lithium content. The rate of elimination of tritium gas from the body was also investigated in animal studies. The method also appears suitable for the measurement of lithium levels in the kidney.
Author Yasumura, S
Cohn, S H
Ellis, K J
LoMonte, A
Vartsky, D
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Issue 11
Keywords Expired gas
Human
In vivo
Detection limit
Central nervous system
Lithium
Tritium
Concentration
Measurement method
Liquid scintillation
Language English
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SubjectTerms Air - analysis
Animals
Biological and medical sciences
Brain Chemistry
Chlorides
Humans
Investigative techniques, diagnostic techniques (general aspects)
Isotopes
Lithium - analysis
Lithium Chloride
Medical sciences
Radioisotope Dilution Technique
Rats
Respiration
Tritium
Title A proposed method for in vivo determination of lithium in human brain
URI http://iopscience.iop.org/0031-9155/30/11/005
https://www.ncbi.nlm.nih.gov/pubmed/3001792
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