Molecular properties of the papaverine binding sites identified in human colonic membranes with 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl) isoquinoline as probe

• Published in: European journal of pharmacology Vol. 149; no. 3; p. 371
• Main Authors: Servin, A L, Christinaki, H, Viel, C
• Format: Journal Article
• Language: English
• Published: Netherlands 10.05.1988
• Subjects: Affinity Labels; Animals; Binding, Competitive; Colon - metabolism; Humans; In Vitro Techniques; Male; Muscle Relaxation - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - metabolism; Papaverine - analogs & derivatives; Papaverine - metabolism; Rats; Rats, Inbred Strains

The binding sites for papaverine in human intestine were studied with the radioiodinated papaverine derivative, 6,7-dimethoxy-4-(4'-amino,3'-[125I]iodobenzyl)isoquinoline [( 125I]DMABI) as a probe. This drug was shown to bind to two specific binding sites in human colon membranes; one with...