In vivo immunotoxicity evaluation of Gd2O3 nanoprobes prepared by laser ablation in liquid for MRI preclinical applications

• Published in: Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 16; no. 9
• Main Authors: Tian, Xiumei, Guan, Xiaoying, Luo, Ningqi, Yang, Fanwen, Chen, Dihu, Peng, Ye, Zhu, Jixiang, He, Fupo, Li, Li, Chen, Xiaoming
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2014; Springer
• Subjects: Characterization and Evaluation of Materials; Chemistry and Materials Science; Condensed matter: structure, mechanical and thermal properties; Exact sciences and technology; General equipment and techniques; Inorganic Chemistry; Instruments, apparatus, components and techniques common to several branches of physics and astronomy; Lasers; Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties; Materials Science; Nanotechnology; Optical Devices; Optics; Photonics; Physical Chemistry; Physics; Research Paper; Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing; Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties); Laser ablation in liquid; Biocompatibility; Gadolinium; Nanoprobe; Immunotoxicity; NMR imaging; Cytotoxicity; In vivo; Biomedical materials; Endocytosis; Transmission electron microscopy; Stress effects; Laser ablation technique; Microstructure

Gd 2 O 3 nanoprobes prepared by laser ablation in liquid can be used as magnetic resonance imaging contrast agent. However, their immunotoxicity in vivo remains unknown. In this article, the in vitro biocompatibility of the Gd 2 O 3 nanoprobe was evaluated in terms of cell uptake, cell viability, an...