Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age

• Published in: Aging cell p. e70153
• Main Authors: Brodeau, Chloé, Joly, Camille, Chekroun, Anaïs, Nakhle, Jean, Blase, Vincent, Espagnolle, Nicolas, Dray, Cédric, Yart, Armelle, Planat, Valérie, Tertrais, Margot, Fassy, Julien, Guyonnet, Sophie, Lu, Wan‐Hsuan, de Souto Barreto, Philipe, Teste, Olivier, Tremblay‐Franco, Marie, Tanner, Kamaryn T., Cohen, Alan A., Carriere, Audrey, Casteilla, Louis, Ader, Isabelle
• Format: Journal Article
• Language: English
• Published: England Wiley Open Access 01.07.2025
• Subjects: Life Sciences; cellular aging; metabolism; healthy aging; intrinsic capacity; dermal fibroblast; extracellular matrix; Intrinsic Capacity

Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsic capacity (IC), a composite measure of physical and mental c...