The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 12; no. 12; pp. 1809 - 1817
• Main Authors: Dube, J L, Wang, P, Elvin, J, Lyons, K M, Celeste, A J, Matzuk, M M
• Format: Journal Article
• Language: English
• Published: United States 01.12.1998
• Subjects: Amino Acid Sequence; Animals; Blotting, Northern; Bmp15 gene; bone morphogenetic protein 15; Bone Morphogenetic Proteins - chemistry; Bone Morphogenetic Proteins - genetics; Chromosome Mapping; Female; GDF-9 gene; Gene Expression; Genetic Linkage; growth/differentiation factor 9; Humans; In Situ Hybridization; Mice; Molecular Sequence Data; Oocytes - metabolism; Ovary - chemistry; Restriction Mapping; RNA, Messenger - analysis; X Chromosome

We have taken advantage of the sequence relationships among the bone morphogenetic proteins (BMPs) to identify the mouse Bmp15 and human BMP15 genes. The 392-amino acid prepropeptides encoded by these BMP genes exhibit significant homology to each other, although the 70% identity observed between th...