Design of 3-Phenylcoumarins and 3-Thienylcoumarins as Potent Xanthine Oxidase Inhibitors: Synthesis, Biological Evaluation, and Docking Studies

• Published in: ChemMedChem Vol. 18; no. 21; p. e202300400
• Main Authors: Fais, Antonella, Pintus, Francesca, Era, Benedetta, Floris, Sonia, Kumar, Amit, Sarmadhikari, Debapriyo, Sogos, Valeria, Uriarte, Eugenio, Asthana, Shailendra, Matos, Maria Joao
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 02.11.2023; Wiley Subscription Services, Inc
• Subjects: Allopurinol; Antioxidants; Antioxidants - chemistry; Binding; Caco-2 Cells; Cell viability; Chemistry, Medicinal; Coumarin; Cytotoxicity; Enzyme Inhibitors - chemistry; Humans; Hydrogen peroxide; Inhibitors; Kinetics; Life Sciences & Biomedicine; Molecular docking; Molecular Docking Simulation; Pharmacology & Pharmacy; Reactive oxygen species; Science & Technology; Structure-Activity Relationship; Xanthine Oxidase; Hydroxy-3-thienylcoumarins; Xanthine oxidase; Molecular docking; Hydroxy-3-phenylcoumarins

Coumarin scaffold has proven to be promising in the development of bioactive agents, such as xanthine oxidase (XO) inhibitors. Novel hydroxylated 3-arylcoumarins were designed, synthesized, and evaluated for their XO inhibition and antioxidant properties. 3-(3'-Bromophenyl)-5,7-dihydroxycoumari...