Enhanced solubility, permeability, and tabletability of nicorandil by salt and cocrystal formation

• Published in: CrystEngComm Vol. 23; no. 1; pp. 227 - 237
• Main Authors: Mannava, M. K. Chaitanya, Gunnam, Anilkumar, Lodagekar, Anurag, Shastri, Nalini R, Nangia, Ashwini K, Solomon, K. Anand
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 07.01.2021
• Subjects: Acids; Adducts; Angina pectoris; Carboxylic acids; Chloroform; Cocrystallization; Crystal structure; Crystallization; Crystallography; Dicarboxylic acids; Diffusion rate; Dissolution; Fumaric acid; Homology; Hydrogen bonds; Infrared spectroscopy; Mechanical properties; NMR spectroscopy; Oxalic acid; Phase stability; Physical properties; Single crystals; Solubility; Spectrum analysis; Succinic acid; Thermal analysis; Toluene

Cocrystallization is a rational selection crystal engineering approach for the development of novel solid forms with enhanced physicochemical and mechanical properties. Nicorandil (NCR) is a niacinamide vitamin derivative used to treat angina pectoris. A binary solid form screen of NCR with homologo...