Endoscopic ultrasound-guided drainage of pancreatic collections with dedicated metal stents: A nationwide, multicenter, propensity score-matched comparison
The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles. This study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen...
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Published in | Digestive and liver disease Vol. 56; no. 1; pp. 159 - 169 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.01.2024
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Abstract | The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles.
This study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen Apposing Metal Stent (LAMS) or Bi-Flanged Metal Stent (BFMS).
Data from a multicenter series of PFCs treated with LAMS or BFMS at 30 Italian centers during a 5-year period were retrieved. The rate of adverse events (AEs), technical success, clinical success, PFC recurrence were evaluated. To overcome biases, a 1-to-1 match was created using propensity score analysis.
Out of 476 patients, 386 were treated with LAMS and 90 with BFMS, with a median follow-up of 290 days (95% CI 244 to 361). Using propensity score matching, 84 patients were assigned to each group. The incidence of AEs did not differ between the two stents (13.1% versus 15.5%, p = 0.29), mainly bleeding or recurrence rate (4.7% versus 3.5%, p = 1). Technical and clinical success in the BFMS and LAMS groups were 92% versus 95% (p = 0.36) and 91% versus 94% (p = 0.64), respectively.
Our study demonstrates that LAMS and BFMS have comparable safety profiles with similar technical and clinical success rates for EUS-guided PFC drainage. |
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AbstractList | The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles.BACKGROUNDThe new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles.This study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen Apposing Metal Stent (LAMS) or Bi-Flanged Metal Stent (BFMS).AIMSThis study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen Apposing Metal Stent (LAMS) or Bi-Flanged Metal Stent (BFMS).Data from a multicenter series of PFCs treated with LAMS or BFMS at 30 Italian centers during a 5-year period were retrieved. The rate of adverse events (AEs), technical success, clinical success, PFC recurrence were evaluated. To overcome biases, a 1-to-1 match was created using propensity score analysis.METHODSData from a multicenter series of PFCs treated with LAMS or BFMS at 30 Italian centers during a 5-year period were retrieved. The rate of adverse events (AEs), technical success, clinical success, PFC recurrence were evaluated. To overcome biases, a 1-to-1 match was created using propensity score analysis.Out of 476 patients, 386 were treated with LAMS and 90 with BFMS, with a median follow-up of 290 days (95% CI 244 to 361). Using propensity score matching, 84 patients were assigned to each group. The incidence of AEs did not differ between the two stents (13.1% versus 15.5%, p = 0.29), mainly bleeding or recurrence rate (4.7% versus 3.5%, p = 1). Technical and clinical success in the BFMS and LAMS groups were 92% versus 95% (p = 0.36) and 91% versus 94% (p = 0.64), respectively.RESULTSOut of 476 patients, 386 were treated with LAMS and 90 with BFMS, with a median follow-up of 290 days (95% CI 244 to 361). Using propensity score matching, 84 patients were assigned to each group. The incidence of AEs did not differ between the two stents (13.1% versus 15.5%, p = 0.29), mainly bleeding or recurrence rate (4.7% versus 3.5%, p = 1). Technical and clinical success in the BFMS and LAMS groups were 92% versus 95% (p = 0.36) and 91% versus 94% (p = 0.64), respectively.Our study demonstrates that LAMS and BFMS have comparable safety profiles with similar technical and clinical success rates for EUS-guided PFC drainage.CONCLUSIONOur study demonstrates that LAMS and BFMS have comparable safety profiles with similar technical and clinical success rates for EUS-guided PFC drainage. The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy and safety profiles. This study aimed to evaluate the safety, technical and clinical success, and recurrence rate of PFCs drained with Lumen Apposing Metal Stent (LAMS) or Bi-Flanged Metal Stent (BFMS). Data from a multicenter series of PFCs treated with LAMS or BFMS at 30 Italian centers during a 5-year period were retrieved. The rate of adverse events (AEs), technical success, clinical success, PFC recurrence were evaluated. To overcome biases, a 1-to-1 match was created using propensity score analysis. Out of 476 patients, 386 were treated with LAMS and 90 with BFMS, with a median follow-up of 290 days (95% CI 244 to 361). Using propensity score matching, 84 patients were assigned to each group. The incidence of AEs did not differ between the two stents (13.1% versus 15.5%, p = 0.29), mainly bleeding or recurrence rate (4.7% versus 3.5%, p = 1). Technical and clinical success in the BFMS and LAMS groups were 92% versus 95% (p = 0.36) and 91% versus 94% (p = 0.64), respectively. Our study demonstrates that LAMS and BFMS have comparable safety profiles with similar technical and clinical success rates for EUS-guided PFC drainage. |
Author | Berretti, Debora De Nucci, Germana Cugia, Luigi Grassia, Roberto Coppola, Franco Fusaroli, Pietro Forti, Edoardo Togliani, Thomas Brancaccio, Mario Luciano Attili, Fabia Binda, Cecilia Petrone, Maria Chiara Badas, Roberta Fabbri, Carlo Lovera, Mauro Tasini, Enrico Facciorusso, Antonio Lisotti, Andrea Redaelli, Alessandro Crinò, Stefano Francesco Leone, Nicola Mutignani, Massimiliano Traina, Mario Ballarè, Marco Manno, Mauro Tarantino, Ilaria Mitri, Roberto Di D'Errico, Francesca DeAngelis, Claudio Cipolletta, Fabio Conte, Elisabetta Bernardoni, Laura Anderloni, Andrea Macchiarelli, Raffaele Ofosu, Andrew Arcidiacono, Paolo Giorgio Pollino, Valeria Coluccio, Chiara Camellini, Lorenzo |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37517962$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Contributor | Berretti, Debora Grassia, Roberto Coppola, Franco Fusaroli, Pietro Brancaccio, Mario Luciano Attili, Fabia Binda, Cecilia Petrone, Maria Chiara Badas, Roberta Lovera, Mauro Tasini, Enrico Lisotti, Andrea Redaelli, Alessandro Leone, Nicola Mutignani, Massimiliano Traina, Mario Ballarè, Marco Manno, Mauro D'Errico, Francesca DeAngelis, Claudio Cipolletta, Fabio Conte, Elisabetta Bernardoni, Laura Macchiarelli, Raffaele Arcidiacono, Paolo Giorgio Pollino, Valeria Camellini, Lorenzo |
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Keywords | Bi-flanged metal stents Pancreatic fluid collection Lumen-apposing metal stents |
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Snippet | The new dedicated stents for endoscopic ultrasound (EUS)-guided transluminal drainage of peri‑pancreatic fluid collections (PFCs) demonstrated optimal efficacy... |
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SubjectTerms | Bi-flanged metal stents Lumen-apposing metal stents Pancreatic fluid collection |
Title | Endoscopic ultrasound-guided drainage of pancreatic collections with dedicated metal stents: A nationwide, multicenter, propensity score-matched comparison |
URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1590865823007624 https://dx.doi.org/10.1016/j.dld.2023.07.012 https://www.ncbi.nlm.nih.gov/pubmed/37517962 https://www.proquest.com/docview/2844085260 |
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