The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice

• Published in: The Journal of neuroscience Vol. 30; no. 21; pp. 7369 - 7376
• Main Authors: Dodd, Garron T, Mancini, Giacomo, Lutz, Beat, Luckman, Simon M
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 26.05.2010
• Subjects: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines - pharmacology; Chlorocebus aethiops; Circadian Rhythm - drug effects; Circadian Rhythm - physiology; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior - drug effects; Dronabinol - pharmacology; Drug Administration Routes; Eating - drug effects; Eating - genetics; Food Deprivation - physiology; Green Fluorescent Proteins - genetics; Hemoglobins - pharmacology; Hyperphagia - chemically induced; Hyperphagia - drug therapy; Leptin - deficiency; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines - pharmacology; Naphthalenes - pharmacology; Peptide Fragments - pharmacology; Piperidines - pharmacology; Protein Transport - drug effects; Psychotropic Drugs - pharmacology; Pyrazoles - pharmacology; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 - agonists; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - deficiency; Receptor, Cannabinoid, CB1 - metabolism; Rimonabant; Time Factors; Transfection - methods

Hemopressin is a short, nine amino acid peptide (H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH) isolated from rat brain that behaves as an inverse agonist at the cannabinoid receptor CB(1), and is shown here to inhibit agonist-induced receptor internalization in a heterologous cell model. Since this pept...