Matrix metalloproteinases and metastasis

• Published in: Cancer chemotherapy and pharmacology Vol. 43; no. 7; pp. S42 - S51
• Main Authors: Kleiner, David E., Stetler-Stevenson, William G.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Berlin Springer 1999
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Cell Adhesion; Gelatinases - metabolism; Host-tumor relations. Immunology. Biological markers; Humans; Matrix Metalloproteinase 2; Medical sciences; Metalloendopeptidases - metabolism; Molecular Sequence Data; Neoplasm Invasiveness; Neoplasm Metastasis - pathology; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tumors; Peptidases; Enzymatic activity; Enzyme; Tumor progression; Enzyme inhibitor; Hydrolases; Metalloendopeptidases; Advanced stage; Review; Metastasis; Malignant tumor; Aminoacid sequence

Metastatic disease is responsible for the majority of cancer-related deaths, either directly due to tumor involvement of critical organs or indirectly due to complications of therapy to control tumor growth and spread. An understanding of the mechanisms of tumor cell invasion and metastasis may be i...