Renal uptake and degradation of trapped-label insulin

• Published in: Renal physiology and biochemistry Vol. 12; no. 4; p. 228
• Main Authors: Hysing, J, Tolleshaug, H, Kindberg, G M
• Format: Journal Article
• Language: English
• Published: Switzerland 01.07.1989
• Subjects: Animals; Cellobiose; Chromatography, Gel; Insulin - metabolism; Insulin - pharmacology; Kidney - metabolism; Kinetics; Liver - metabolism; Male; Molecular Weight; Rats; Rats, Inbred Strains; Tyramine

In order to study the kinetics of insulin degradation in the kidneys and liver, insulin was labelled by a trapped-label procedure and injected into rats. In contrast to conventional 125I-insulin, the trapped-label preparation allows quantitative measurements of the extent of degradation in vivo beca...