Simultaneous cyclic deracemisation and stereoinversion of alcohols using orthogonal biocatalytic oxidation and reduction reactions

• Published in: Catalysis science & technology Vol. 1; no. 24; pp. 8213 - 8218
• Main Authors: Nafiu, Sodiq A, Takahashi, Masateru, Takahashi, Etsuko, Hamdan, Samir M, Musa, Musa M
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 21.12.2020
• Subjects: Alcohol; Alcohol dehydrogenase; Chemical reduction; Oxidation; Regeneration; Stereoselectivity; Strategy

We developed a concurrent cyclic deracemisation approach for secondary alcohols that combines a non-stereospecific oxidation step and a stereoselective reduction step using two mutants of Thermoanaerobacter pseudoethanolicus secondary alcohol dehydrogenase ( Te SADH) that exhibit various extents of...