Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with maturity-onset diabetes of the young

• Published in: Diabetologia Vol. 43; no. 1; pp. 121 - 124
• Main Authors: Yamada, S., Zhu, Q., Aihara, Y., Onda, H., Zhang, Z., Yu, L., Jin, L., Si, Y. -J., Nishigori, H., Tomura, H., Inoue, I., Morikawa, A., Yamagata, K., Hanafusa, T., Matsuzawa, Y., Takeda, J.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.01.2000
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Biological and medical sciences; Chromosome Mapping; Chromosomes, Human, Pair 20; Cloning, Molecular; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; DNA Mutational Analysis; DNA, Complementary; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exons; Gene Library; Genomic Library; Hepatocyte Nuclear Factor 3-beta; Humans; Introns; Japan; Liver - metabolism; Medical sciences; Mice; Molecular Sequence Data; Nuclear Proteins - chemistry; Nuclear Proteins - genetics; Rats; Recombinant Proteins - chemistry; Sequence Alignment; Sequence Homology, Amino Acid; Transcription Factors - genetics; Xenopus; Zebrafish; Japan; Endocrinopathy; Human; Maturity onset diabetes young; Pancreatic hormone; Transcription; Genetics; Mutation; Molecular cloning; Insulin; Japanese; Transcription factor HNF; Endocrine secretion

Molecular defects of the genes for transcription factors, hepatocyte nuclear factor (HNF)-4 alpha, HNF-1 alpha, HNF-1 beta and insulin promoter factor-1 cause maturity-onset diabetes of the young (MODY1, 3, 5, and 4, respectively). This suggests the HNF-related transcription cascade is important in...