Investigating the solubilization effect of oxcarbazepine by forming cocrystals

• Published in: CrystEngComm Vol. 21; no. 32; pp. 4718 - 4729
• Main Authors: Li, Xiangrong, Yu, Guojia, Chen, Xinjian, He, Lichao, Zhou, Zhiyong, Ren, Zhongqi
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 2019
• Subjects: Carbonyl groups; Carbonyls; Crystallization; Differential scanning calorimetry; Dihydroxybenzoic acid; Fourier transforms; Functional groups; Hydrogen bonds; Infrared analysis; NMR; Nuclear magnetic resonance; Oxalic acid; Salicylic acid; Solubility; Solubilization; Spectrum analysis; Thermogravimetric analysis; X ray powder diffraction

Oxcarbazepine (OXCBZ) is a poorly soluble drug that can't form a salt. It has an amide functional group and a carbonyl group in its structure, which can be used to form cocrystals. Three cocrystals of OXCBZ were successfully synthesized through liquid-assisted grinding and reaction crystallizat...