Hexadecylphosphocholine does not influence phospholipase D and sphingomyelinase activity in human leukemia cells

• Published in: Journal of experimental therapeutics & oncology Vol. 2; no. 4; p. 213
• Main Authors: Berkovic, Dinko, Berkovic, Katharina, Binder, Claudia, Haase, Detlef, Fleer, Eduard A M
• Format: Journal Article
• Language: English
• Published: United States 01.07.2002
• Subjects: Cell Division - drug effects; Humans; Leukemia - enzymology; Phospholipase D - metabolism; Phosphorylcholine - analogs & derivatives; Phosphorylcholine - pharmacology; Sphingomyelin Phosphodiesterase - metabolism; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha - metabolism

Hexadecylphosphocholine (HePC) is the first representative of the alkylphosphocholines (APC), a new group of biologically active compounds. HePC has pronounced antiproliferative effects on neoplastic cells in vitro and in vivo. The molecular mechanism by which HePC exerts its biological effects is s...