Pharmacokinetics and clinical efficacy of rectal apomorphine in patients with Parkinson's disease: a study of five different suppositories

• Published in: Movement disorders Vol. 10; no. 4; p. 433
• Main Authors: van Laar, T, Jansen, E N, Neef, C, Danhof, M, Roos, R A
• Format: Journal Article
• Language: English
• Published: United States 01.07.1995
• Subjects: Aged; Antiparkinson Agents - administration & dosage; Antiparkinson Agents - adverse effects; Antiparkinson Agents - pharmacokinetics; Apomorphine - administration & dosage; Apomorphine - adverse effects; Apomorphine - pharmacokinetics; Biological Availability; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Drug Therapy, Combination; Exercise Test - drug effects; Female; Humans; Levodopa - adverse effects; Levodopa - therapeutic use; Male; Middle Aged; Neurologic Examination - drug effects; Parkinson Disease - blood; Parkinson Disease - drug therapy; Suppositories; Treatment Outcome

The pharmacokinetics and clinical effects of apomorphine after rectal administration were determined in five patients with idiopathic Parkinson's disease (PD). Three different pharmaceutical formulations were tested: a rectal solution of apomorphine (10 or 15 mg), a gelatin suppository (25 and...