Minor Histocompatibility Antigens Are Expressed in Syncytiotrophoblast and Trophoblast Debris

• Published in: The American journal of pathology Vol. 180; no. 1; pp. 256 - 266
• Main Authors: Holland, Olivia J, Linscheid, Caitlin, Hodes, Herbert C, Nauser, Traci L, Gilliam, Melissa, Stone, Peter, Chamley, Larry W, Petroff, Margaret G
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2012
• Subjects: Pathology

The fetal semi-allograft can induce expansion and tolerance of antigen-specific maternal T and B cells through paternally inherited major histocompatibility complex and minor histocompatibility antigens (mHAgs). The effects of these antigens have important consequences on the maternal immune system...