Alternative Th17 and CD4+CD25+FoxP3+ cell frequencies increase and correlate with worse cardiac function in Chagas cardiomyopathy
Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+CD25+FoxP3+ cells, classic Th17 cells, altern...
Saved in:
Published in | Scandinavian journal of immunology Vol. 87; no. 4; pp. e12650 - n/a |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Wiley Subscription Services, Inc
01.04.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+CD25+FoxP3+ cells, classic Th17 cells, alternative Th17 cells and IL‐17+ B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4+CD25+FoxP3+, CD4+CD25highFoxP3+, CD4+IL‐17+IFN‐γ− and CD4+IL‐17+IFN‐γ+ cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4+CD25+FoxP3+ and CD4+IL‐17+IFN‐γ− Th17 cells, this relationship was not observed in cardiac patients. IL‐17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. |
---|---|
AbstractList | Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4
CD25
FoxP3
cells, classic Th17 cells, alternative Th17 cells and IL-17
B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4
CD25
FoxP3
, CD4
CD25
FoxP3
, CD4
IL-17
IFN-γ
and CD4
IL-17
IFN-γ
cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4
CD25
FoxP3
and CD4
IL-17
IFN-γ
Th17 cells, this relationship was not observed in cardiac patients. IL-17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+ CD25+ FoxP3+ cells, classic Th17 cells, alternative Th17 cells and IL-17+ B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4+ CD25+ FoxP3+ , CD4+ CD25high FoxP3+ , CD4+ IL-17+ IFN-γ- and CD4+ IL-17+ IFN-γ+ cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4+ CD25+ FoxP3+ and CD4+ IL-17+ IFN-γ- Th17 cells, this relationship was not observed in cardiac patients. IL-17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+CD25+FoxP3+ cells, classic Th17 cells, alternative Th17 cells and IL‐17+ B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4+CD25+FoxP3+, CD4+CD25highFoxP3+, CD4+IL‐17+IFN‐γ− and CD4+IL‐17+IFN‐γ+ cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4+CD25+FoxP3+ and CD4+IL‐17+IFN‐γ− Th17 cells, this relationship was not observed in cardiac patients. IL‐17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. Abstract Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD 4 + CD 25 + FoxP3 + cells, classic Th17 cells, alternative Th17 cells and IL ‐17 + B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 ( CARD 1) (n = 20) and severe, C ( CARD 2) (n = 11). Patients with the indeterminate form of CD were included as the control group A ( IND ) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity ( MFI ) were obtained by flow cytometry. Our results showed that only CD 4 + CD 25 + FoxP3 + , CD 4 + CD 25 high FoxP3 + , CD 4 + IL ‐17 + IFN ‐γ − and CD 4 + IL ‐17 + IFN ‐γ + cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD 4 + CD 25 + FoxP3 + and CD 4 + IL ‐17 + IFN ‐γ − Th17 cells, this relationship was not observed in cardiac patients. IL ‐17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors involved have not been fully elucidated. Therefore, our study aimed to analyse the frequency of CD4+CD25+FoxP3+ cells, classic Th17 cells, alternative Th17 cells and IL‐17+ B cells from peripheral blood of chronic cardiac patients after in vitro stimulation with Trypanosoma cruzi soluble EPI antigen. Patients were selected and classified according to clinical evaluation of cardiac involvement: mild, B1 (CARD1) (n = 20) and severe, C (CARD2) (n = 11). Patients with the indeterminate form of CD were included as the control group A (IND) (n = 17). Blood samples were collected and cultured in the presence of EPI antigen. Cells frequency and median fluorescence intensity (MFI) were obtained by flow cytometry. Our results showed that only CD4+CD25+FoxP3+, CD4+CD25highFoxP3+, CD4+IL‐17+IFN‐γ− and CD4+IL‐17+IFN‐γ+ cells are more frequent in patients with severe cardiac disease and correlate with worse global cardiac function. However, while indeterminate patients demonstrated a positive correlation between CD4+CD25+FoxP3+ and CD4+IL‐17+IFN‐γ− Th17 cells, this relationship was not observed in cardiac patients. IL‐17 expression by Th17 cells and B cells correlated with disease progression. Altogether our results suggest that the clinical progression of Chagas cardiomyopathy involves worsening of inflammation and impairment of immunoregulatory mechanisms. |
Author | Martins, S. M. Lorena, V. M. B. Cavalcanti, M. da G. A. M. Almeida, M. S. Junior, W. O. de Morais, C. N. L. Medeiros, C. de A. |
Author_xml | – sequence: 1 givenname: M. S. surname: Almeida fullname: Almeida, M. S. organization: FIOCRUZ – sequence: 2 givenname: V. M. B. orcidid: 0000-0003-0663-236X surname: Lorena fullname: Lorena, V. M. B. email: lorena@cpqam.fiocruz.br organization: FIOCRUZ – sequence: 3 givenname: C. de A. surname: Medeiros fullname: Medeiros, C. de A. organization: University of Pernambuco (UPE) – sequence: 4 givenname: W. O. surname: Junior fullname: Junior, W. O. organization: University of Pernambuco (UPE) – sequence: 5 givenname: M. da G. A. M. surname: Cavalcanti fullname: Cavalcanti, M. da G. A. M. organization: University of Pernambuco (UPE) – sequence: 6 givenname: S. M. surname: Martins fullname: Martins, S. M. organization: University of Pernambuco (UPE) – sequence: 7 givenname: C. N. L. surname: de Morais fullname: de Morais, C. N. L. organization: FIOCRUZ |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29473686$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kcFu1DAURS1URKeFBT-ALLEBjdLacRI7yyptoahSkSjr6MV5ZjzK2IOdMJ0lf46nKSyQ6o0lv-Mj3XdPyJHzDgl5y9kZT-c8ru0Zz6uSvSALLqoyE0yJI7JggrGsLmR5TE5iXDPGRS7FK3Kcp0dRqWpBfl8MIwYHo_2F9H7FJQXX0-ayWDaXebm89g9fxZJqHAZqAv6c0GmLkVqnA0LER1r7EHCAEenOjiu68yENNITegqZmcnq03qUvtFnBD4jzyG_2fgvjav-avDQwRHzzdJ-S79dX983n7Pbu001zcZtpwRXLpOyMBkRZV1BgoQrBTM37FBcMzwGY6UGk7NKg6jqFptaSoRbIjBadLsQp-TB7t8GnHHFsNzYegoFDP8U2Z0zWSrGySuj7_9C1n9KShgPFZc2kUgfhx5nSwccY0LTbYDcQ9i1n7aGXNvXSPvaS2HdPxqnbYP-P_FtEAs5nYGcH3D9var99uZmVfwA7MJkZ |
CitedBy_id | crossref_primary_10_1016_j_vaccine_2019_05_015 crossref_primary_10_1016_j_imbio_2021_152166 crossref_primary_10_1038_s41598_020_61965_5 crossref_primary_10_1016_j_actatropica_2022_106452 crossref_primary_10_1016_j_bbadis_2020_165706 crossref_primary_10_3389_fimmu_2021_732794 crossref_primary_10_1590_s1678_9946201860057 crossref_primary_10_1038_s41398_020_01105_9 crossref_primary_10_1111_pim_13024 crossref_primary_10_3389_fimmu_2020_572178 |
Cites_doi | 10.1371/journal.pone.0065820 10.1155/2014/651503 10.1111/j.1365-3083.2005.01668.x 10.4049/jimmunol.180.11.7112 10.1016/j.coi.2011.08.007 10.1111/j.1365-3083.2010.02462.x 10.1002/jcp.22331 10.1038/ni904 10.4049/jimmunol.0900047 10.1128/CMR.00063-10 10.1002/eji.201343604 10.1016/j.cell.2008.05.009 10.1016/j.micinf.2008.03.008 10.1016/j.micinf.2008.04.009 10.1128/IAI.71.3.1185-1193.2003 10.1128/IAI.01500-06 10.1016/j.imbio.2012.04.008 10.1016/j.pt.2005.09.007 10.1007/s00011-011-0419-1 10.1371/journal.ppat.1002658 10.4049/jimmunol.0803821 10.1590/S0074-02762009000900006 10.1093/infdis/jis640 10.1136/annrheumdis-2013-204228 10.1086/653738 10.2741/E495 10.1016/j.immuni.2008.05.007 10.1038/ni.2569 10.1002/eji.1830271202 10.1038/nm.3432 10.1038/ni1181 10.1007/s10875-014-0092-6 10.1371/journal.pone.0087082 10.1371/journal.pntd.0001630 10.4049/jimmunol.167.3.1245 10.4049/jimmunol.1103478 10.1016/j.idc.2012.03.002 10.1016/j.clim.2009.11.008 10.1590/S0066-782X2011000600002 10.1016/j.immuni.2009.05.001 10.1016/j.clim.2004.01.002 10.1111/j.1365-2249.2006.03123.x 10.1016/j.coph.2014.06.004 10.1155/2014/914326 10.1146/annurev.immunol.24.021605.090547 10.1093/infdis/jis724 10.1111/pim.12107 10.1038/nri2785 10.1371/journal.ppat.1003243 |
ContentType | Journal Article |
Copyright | 2018 The Foundation for the Scandinavian Journal of Immunology 2018 The Foundation for the Scandinavian Journal of Immunology. Copyright © 2018 The Foundation for the Scandinavian Journal of Immunology |
Copyright_xml | – notice: 2018 The Foundation for the Scandinavian Journal of Immunology – notice: 2018 The Foundation for the Scandinavian Journal of Immunology. – notice: Copyright © 2018 The Foundation for the Scandinavian Journal of Immunology |
DBID | NPM AAYXX CITATION 7QP 7QR 7T5 7TK 7U9 8FD FR3 H94 K9. M7N NAPCQ P64 7X8 |
DOI | 10.1111/sji.12650 |
DatabaseName | PubMed CrossRef Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Virology and AIDS Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef Nursing & Allied Health Premium Virology and AIDS Abstracts Technology Research Database Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Chemoreception Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | PubMed MEDLINE - Academic Nursing & Allied Health Premium CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Biology |
EISSN | 1365-3083 |
EndPage | n/a |
ExternalDocumentID | 10_1111_sji_12650 29473686 SJI12650 |
Genre | article Journal Article |
GroupedDBID | --- -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 123 1OB 1OC 24P 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABOCM ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOETA ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EAS EBC EBD EBS EBX EJD EMB EMK EMOBN EPT ESX EX3 F00 F01 F04 F5P FEDTE FIJ FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IH2 IHE IPNFZ IX1 J0M J5H K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OBS OHT OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 Q~Q R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 Y6R YFH YOC YUY ZGI ZXP ZZTAW ~IA ~KM ~WT NPM AAYXX CITATION 7QP 7QR 7T5 7TK 7U9 8FD FR3 H94 K9. M7N NAPCQ P64 7X8 |
ID | FETCH-LOGICAL-c3180-77bfcaee796a4e48430f91d136af12aa0fda33657fe8bb8ef9c70ec3e0fc3bc43 |
IEDL.DBID | DR2 |
ISSN | 0300-9475 |
IngestDate | Wed Jul 24 14:17:02 EDT 2024 Thu Oct 10 20:20:23 EDT 2024 Fri Aug 23 04:04:10 EDT 2024 Wed Oct 16 00:59:39 EDT 2024 Sat Aug 24 00:51:04 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | cardiomyopathy Th17 Chagas Treg interleukin 17 |
Language | English |
License | 2018 The Foundation for the Scandinavian Journal of Immunology. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3180-77bfcaee796a4e48430f91d136af12aa0fda33657fe8bb8ef9c70ec3e0fc3bc43 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-0663-236X |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/sji.12650 |
PMID | 29473686 |
PQID | 2017907884 |
PQPubID | 37516 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_2007988056 proquest_journals_2017907884 crossref_primary_10_1111_sji_12650 pubmed_primary_29473686 wiley_primary_10_1111_sji_12650_SJI12650 |
PublicationCentury | 2000 |
PublicationDate | April 2018 2018-Apr 2018-04-00 20180401 |
PublicationDateYYYYMMDD | 2018-04-01 |
PublicationDate_xml | – month: 04 year: 2018 text: April 2018 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: Oxford |
PublicationTitle | Scandinavian journal of immunology |
PublicationTitleAlternate | Scand J Immunol |
PublicationYear | 2018 |
Publisher | Wiley Subscription Services, Inc |
Publisher_xml | – name: Wiley Subscription Services, Inc |
References | 2012; 61 2010; 10 2013; 207 2015; 74 2013; 20 2005; 62 2011; 96 2010; 185 2005; 21 2016; 2016 2007; 75 2013; 8 2013; 9 2013; 14 2006; 24 2008; 29 2003; 4 2011; 24 2011; 23 2012; 26 2014; 17 2014; 9 2012; 217 2010; 72 2001; 167 2012; 188 2009; 182 2010; 202 2006; 59 1997; 27 2008; 10 2014; 2014 2003; 71 2006; 116 2014; 44 2011; 226 2004; 111 2008; 180 2009; 30 2010; 135 2014; 36 2005; 6 2012; 6 2008; 133 2012; 4 2006; 145 2014; 34 2009; 104 2012; 8 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_17_1 e_1_2_7_15_1 e_1_2_7_41_1 López L (e_1_2_7_49_1) 2006; 59 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_28_1 De PCG (e_1_2_7_42_1) 2016; 2016 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_52_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_37_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_27_1 e_1_2_7_29_1 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_53_1 Wang Z (e_1_2_7_48_1) 2006; 116 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_38_1 |
References_xml | – volume: 10 start-page: 825 year: 2008 end-page: 833 article-title: The involvement of CD4+CD25+ T cells in the acute phase of infection publication-title: Microbes Infect – volume: 71 start-page: 1185 year: 2003 end-page: 1193 article-title: Evidence that development of severe cardiomyopathy in human Chagas’ disease is due to a Th1‐specific immune response publication-title: Infect Immun – volume: 226 start-page: 8 year: 2011 end-page: 13 article-title: Reciprocal modulation between TH17 and other helper T cell lineages publication-title: J Cell Physiol – volume: 74 start-page: 1293 year: 2015 end-page: 1301 article-title: Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood publication-title: Ann Rheum Dis – volume: 29 start-page: 44 year: 2008 end-page: 56 article-title: Molecular antagonism and plasticity of regulatory and inflammatory T cell programs publication-title: Immunity – volume: 104 start-page: 31 year: 2009 end-page: 40 article-title: Epidemiology, control and surveillance of Chagas disease: 100 years after its discovery publication-title: Mem Inst Oswaldo Cruz – volume: 8 start-page: e1002658 year: 2012 article-title: IL‐17RA signaling reduces inflammation and mortality during infection by recruiting suppressive IL‐10‐producing neutrophils publication-title: PLoS Pathog – volume: 10 start-page: 490 year: 2010 end-page: 500 article-title: FOXP3+ regulatory T cells in the human immune system publication-title: Nat Rev Immunol – volume: 188 start-page: 3766 year: 2012 end-page: 3773 article-title: Regulation of proinflammatory Th17 Responses during infection by IL‐12 family cytokines publication-title: J Immunol – volume: 72 start-page: 529 year: 2010 end-page: 539 article-title: Cytokine levels in serious cardiopathy of chagas disease after in vitro stimulation with recombinant antigens from publication-title: Scand J Immunol – volume: 4 start-page: 330 year: 2003 end-page: 336 article-title: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells publication-title: Nat Immunol – volume: 207 start-page: 152 year: 2013 end-page: 163 article-title: Association of a NOD2 gene polymorphism and T‐helper 17 cells with presumed ocular toxoplasmosis publication-title: J Infect Dis – volume: 135 start-page: 108 year: 2010 end-page: 117 article-title: Increased Th17 cells are accompanied by FoxP3+ Treg cell accumulation and correlated with psoriasis disease severity publication-title: Clin Immunol – volume: 2014 start-page: 914326 year: 2014 article-title: Myocardial gene expression of T‐bet, GATA‐3, Ror‐γ t, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: an essentially unopposed T‐Type response publication-title: Mediators Inflamm – volume: 182 start-page: 6179 year: 2009 end-page: 6186 article-title: T‐bet inhibits the in vivo differentiation of parasite‐specific CD4 Th17 cells in a T cell‐intrinsic manner publication-title: J Immunol – volume: 17 start-page: 12 year: 2014 end-page: 16 article-title: Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders publication-title: Curr Opin Pharmacol – volume: 2016 start-page: 3694714 year: 2016 article-title: Doxycycline and benznidazole reduce the profile of Th1, Th2, and Th17 chemokines and chemokine receptors in cardiac tissue from chronic ‐infected dogs publication-title: Mediators Inflamm – volume: 59 start-page: 50 year: 2006 end-page: 56 article-title: C‐reactive protein and interleukin‐6 serum levels increase as Chagas disease progresses towards cardiac failure publication-title: Rev Española Cardiol – volume: 75 start-page: 861 year: 2007 end-page: 869 article-title: Endogenous CD4+ CD25+ regulatory T cells have a limited role in the control of infection in mice publication-title: Infect Immun – volume: 4 start-page: 1743 year: 2012 end-page: 1758 article-title: Pathogenesis of Chagas disease: time to move on publication-title: Front Biosci (Elite Ed) – volume: 9 start-page: e87082 year: 2014 article-title: Plasma cytokine expression is associated with cardiac morbidity in chagas disease publication-title: PLoS One – volume: 9 start-page: e1003243 year: 2013 article-title: IL‐17 mediates immunopathology in the absence of IL‐10 following leishmania major infection publication-title: PLoS Pathog – volume: 44 start-page: 1069 year: 2014 end-page: 1083 article-title: Expansion of Foxp3+T‐cell populations by enhances both Th17‐cell responses and fungal dissemination after intravenous challenge publication-title: Eur J Immunol – volume: 24 start-page: 592 year: 2011 end-page: 630 article-title: Pathogenesis of chagas’ disease: parasite persistence and autoimmunity publication-title: Clin Microbiol Rev – volume: 6 start-page: e1630 year: 2012 article-title: Deficient regulatory T cell activity and low frequency of IL‐17‐producing T cells correlate with the extent of cardiomyopathy in human Chagas’ disease publication-title: PLoS Negl Trop Dis – volume: 30 start-page: 646 year: 2009 end-page: 655 article-title: Plasticity of CD4+ T cell lineage differentiation publication-title: Immunity – volume: 34 start-page: 991 year: 2014 end-page: 998 article-title: Increase in the expression of CD4+ CD25+ lymphocytic T cells in the indeterminate clinical form of human Chagas disease after stimulation with recombinant antigens of publication-title: J Clin Immunol – volume: 202 start-page: 427 year: 2010 end-page: 435 article-title: Interleukin 17 receptor signaling is deleterious during infection in susceptible BL6 mice publication-title: J Infect Dis – volume: 2014 start-page: 651503 year: 2014 article-title: Th17 cells in autoimmune and infectious diseases publication-title: Int J Inflam – volume: 62 start-page: 297 year: 2005 end-page: 308 article-title: Chagasic patients with indeterminate clinical form of the disease have high frequencies of circulating CD3+CD16‐CD56+ natural killer T cells and CD4+CD25High regulatory T lymphocytes publication-title: Scand J Immunol – volume: 96 start-page: 434 year: 2011 end-page: 442 article-title: I Latin American Guidelines for the diagnosis and treatment of chagas’ heart disease: executive summary publication-title: Arq Bras Cardiol – volume: 133 start-page: 775 year: 2008 end-page: 787 article-title: Regulatory T cells and immune tolerance publication-title: Cell – volume: 14 start-page: 514 year: 2013 end-page: 522 article-title: trans‐sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL‐17 production by activated B cells publication-title: Nat Immunol – volume: 23 start-page: 702 year: 2011 end-page: 706 article-title: The many faces of Th17 cells publication-title: Curr Opin Immunol – volume: 207 start-page: 661 year: 2013 end-page: 665 article-title: High interleukin 17 expression is correlated with better cardiac function in human Chagas disease publication-title: J Infect Dis – volume: 61 start-page: 87 year: 2012 end-page: 96 article-title: Th17 cell cytokine secretion profile in host defense and autoimmunity publication-title: Inflamm Res – volume: 185 start-page: 1150 year: 2010 end-page: 1157 article-title: IL‐17 is necessary for host protection against acute‐phase infection publication-title: J Immunol – volume: 26 start-page: 275 year: 2012 end-page: 291 article-title: American trypanosomiasis (Chagas disease) publication-title: Infect Dis Clin North Am – volume: 8 start-page: e65820 year: 2013 article-title: Analysis of the dynamics of infiltrating CD4+ T cell subsets in the heart during experimental infection publication-title: PLoS One – volume: 36 start-page: 377 year: 2014 end-page: 387 article-title: Immunoregulatory networks in human Chagas disease publication-title: Parasite Immunol – volume: 217 start-page: 768 year: 2012 end-page: 777 article-title: Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity publication-title: Immunobiology – volume: 24 start-page: 209 year: 2006 end-page: 226 article-title: FOXP3: of mice and men publication-title: Annu Rev Immunol – volume: 145 start-page: 81 year: 2006 end-page: 92 article-title: Are increased frequency of macrophage‐like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas’ disease morbidity? publication-title: Clin Exp Immunol – volume: 167 start-page: 1245 year: 2001 end-page: 1253 article-title: CD4+CD25high regulatory cells in human peripheral blood publication-title: J Immunol – volume: 116 start-page: 2434 year: 2006 end-page: 2441 article-title: Role of IFN‐gamma in induction of Foxp3 and conversion of CD4+ CD25‐ T cells to CD4+ Tregs publication-title: J Clin Invest – volume: 10 start-page: 680 year: 2008 end-page: 688 article-title: The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with publication-title: Microbes Infect – volume: 111 start-page: 137 year: 2004 end-page: 145 article-title: Differential regulation of lymphoproliferative responses to antigen in patients with the cardiac or indeterminate form of Chagas disease publication-title: Clin Immunol – volume: 6 start-page: 353 year: 2005 end-page: 360 article-title: Natural regulatory T cells in infectious disease publication-title: Nat Immunol – volume: 20 start-page: 62 year: 2013 end-page: 68 article-title: Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis publication-title: Nat Med – volume: 27 start-page: 3085 year: 1997 end-page: 3094 article-title: ‐infected macrophages are defective in major histocompatibility complex class II antigen presentation publication-title: Eur J Immunol – volume: 21 start-page: 581 year: 2005 end-page: 587 article-title: The clinical immunology of human Chagas disease publication-title: Trends Parasitol – volume: 180 start-page: 7112 year: 2008 end-page: 7116 article-title: Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL‐2 and TGF‐ are resistant to Th17 conversion by IL‐6 publication-title: J Immunol – ident: e_1_2_7_50_1 doi: 10.1371/journal.pone.0065820 – ident: e_1_2_7_27_1 doi: 10.1155/2014/651503 – volume: 59 start-page: 50 year: 2006 ident: e_1_2_7_49_1 article-title: C‐reactive protein and interleukin‐6 serum levels increase as Chagas disease progresses towards cardiac failure publication-title: Rev Española Cardiol contributor: fullname: López L – ident: e_1_2_7_14_1 doi: 10.1111/j.1365-3083.2005.01668.x – ident: e_1_2_7_52_1 doi: 10.4049/jimmunol.180.11.7112 – ident: e_1_2_7_29_1 doi: 10.1016/j.coi.2011.08.007 – ident: e_1_2_7_7_1 doi: 10.1111/j.1365-3083.2010.02462.x – ident: e_1_2_7_32_1 doi: 10.1002/jcp.22331 – ident: e_1_2_7_35_1 doi: 10.1038/ni904 – ident: e_1_2_7_21_1 doi: 10.4049/jimmunol.0900047 – ident: e_1_2_7_9_1 doi: 10.1128/CMR.00063-10 – ident: e_1_2_7_47_1 doi: 10.1002/eji.201343604 – ident: e_1_2_7_12_1 doi: 10.1016/j.cell.2008.05.009 – ident: e_1_2_7_19_1 doi: 10.1016/j.micinf.2008.03.008 – ident: e_1_2_7_18_1 doi: 10.1016/j.micinf.2008.04.009 – ident: e_1_2_7_6_1 doi: 10.1128/IAI.71.3.1185-1193.2003 – ident: e_1_2_7_17_1 doi: 10.1128/IAI.01500-06 – ident: e_1_2_7_15_1 doi: 10.1016/j.imbio.2012.04.008 – ident: e_1_2_7_41_1 doi: 10.1016/j.pt.2005.09.007 – ident: e_1_2_7_20_1 doi: 10.1007/s00011-011-0419-1 – ident: e_1_2_7_22_1 doi: 10.1371/journal.ppat.1002658 – ident: e_1_2_7_44_1 doi: 10.4049/jimmunol.0803821 – ident: e_1_2_7_2_1 doi: 10.1590/S0074-02762009000900006 – ident: e_1_2_7_26_1 doi: 10.1093/infdis/jis640 – ident: e_1_2_7_45_1 doi: 10.1136/annrheumdis-2013-204228 – ident: e_1_2_7_40_1 doi: 10.1086/653738 – ident: e_1_2_7_10_1 doi: 10.2741/E495 – ident: e_1_2_7_51_1 doi: 10.1016/j.immuni.2008.05.007 – ident: e_1_2_7_28_1 doi: 10.1038/ni.2569 – ident: e_1_2_7_37_1 doi: 10.1002/eji.1830271202 – ident: e_1_2_7_53_1 doi: 10.1038/nm.3432 – volume: 116 start-page: 2434 year: 2006 ident: e_1_2_7_48_1 article-title: Role of IFN‐gamma in induction of Foxp3 and conversion of CD4+ CD25‐ T cells to CD4+ Tregs publication-title: J Clin Invest contributor: fullname: Wang Z – ident: e_1_2_7_11_1 doi: 10.1038/ni1181 – ident: e_1_2_7_16_1 doi: 10.1007/s10875-014-0092-6 – ident: e_1_2_7_39_1 doi: 10.1371/journal.pone.0087082 – ident: e_1_2_7_23_1 doi: 10.1371/journal.pntd.0001630 – ident: e_1_2_7_34_1 doi: 10.4049/jimmunol.167.3.1245 – ident: e_1_2_7_43_1 doi: 10.4049/jimmunol.1103478 – ident: e_1_2_7_3_1 doi: 10.1016/j.idc.2012.03.002 – ident: e_1_2_7_46_1 doi: 10.1016/j.clim.2009.11.008 – ident: e_1_2_7_33_1 doi: 10.1590/S0066-782X2011000600002 – ident: e_1_2_7_31_1 doi: 10.1016/j.immuni.2009.05.001 – volume: 2016 start-page: 3694714 year: 2016 ident: e_1_2_7_42_1 article-title: Doxycycline and benznidazole reduce the profile of Th1, Th2, and Th17 chemokines and chemokine receptors in cardiac tissue from chronic Trypanosoma cruzi‐infected dogs publication-title: Mediators Inflamm contributor: fullname: De PCG – ident: e_1_2_7_5_1 doi: 10.1016/j.clim.2004.01.002 – ident: e_1_2_7_8_1 doi: 10.1111/j.1365-2249.2006.03123.x – ident: e_1_2_7_30_1 doi: 10.1016/j.coph.2014.06.004 – ident: e_1_2_7_38_1 doi: 10.1155/2014/914326 – ident: e_1_2_7_36_1 doi: 10.1146/annurev.immunol.24.021605.090547 – ident: e_1_2_7_24_1 doi: 10.1093/infdis/jis724 – ident: e_1_2_7_4_1 doi: 10.1111/pim.12107 – ident: e_1_2_7_13_1 doi: 10.1038/nri2785 – ident: e_1_2_7_25_1 doi: 10.1371/journal.ppat.1003243 |
SSID | ssj0013273 |
Score | 2.3096235 |
Snippet | Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic factors... Abstract Immune homeostasis has been suggested to play an important role in the clinical evolution of chronic Chagas disease; however, the immunopathologic... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | e12650 |
SubjectTerms | Antigens Cardiomyopathy CD25 antigen CD4 antigen Chagas Chagas' disease Coronary artery disease Flow cytometry Fluorescence Foxp3 protein Heart diseases Helper cells Homeostasis Immunoregulation Interferon interleukin 17 Lymphocytes B Lymphocytes T Peripheral blood Th17 Treg Vector-borne diseases |
Title | Alternative Th17 and CD4+CD25+FoxP3+ cell frequencies increase and correlate with worse cardiac function in Chagas cardiomyopathy |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fsji.12650 https://www.ncbi.nlm.nih.gov/pubmed/29473686 https://www.proquest.com/docview/2017907884 https://search.proquest.com/docview/2007988056 |
Volume | 87 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEB9KRfGlatX2tJYoPgjHHrubbDaLT9c7j1qoiLbQB2FJsomt1l25vVPON_9zJ8nu0SqC-LYwCdlN5uOXmdkZgOeZFKLiPIsUwysKWozKOZpYhDJepVLmNFXO33H8hh-esqOz7GwDXvb_woT6EGuHm5MMr6-dgEvVXhHy9tPFKEm5v68nNHfpXNN36ZUIQogu0ziOCpZnXVUhl8WznnndFv0BMK_jVW9wZnfgQ_-qIc_k82i5UCP947cqjv_5LXdhqwOiZBw45x5smHobbobWlKttuHXcBd3vw8_xZec1_GbIyXmSE1lXZDJlw8k0zYZov97SIXERAGLnITMbr9_konaAtDV-tHZNQC4R1xLn-CXfmzkStOdOTZxtdfyBU8jkXH6UbSA1X1aN65i8egCns1cnk8Oo69wQadQRMUJ2ZbU0Ji-4ZIYJRmNbJFVCubQJskBsK0kpz3JrhFLC2ELnsdHUxFZTpRl9CJt1U5tdIFpIiZCr0IZXLElNgQhTpFajJlKW2WwAz_ozLL-GAh1lf7HBbS39tg5grz_dspPRtkydMkKEJNgAnq7JKF1uw2RtmqUbE7uCbogSB7ATuGK9SopsRblAygt_tn9fvnx_9No_PPr3oY_hNr6gCElCe7C5mC_NE8Q_C7UPN8YH04PZvmf4XxaeAbI |
link.rule.ids | 315,783,787,1378,27938,27939,46310,46734 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRTwuPAqFhQIGcUBaZZXETuJIXKpdqm3pVgi2Ui8osh2bFkqC9gFabvxzZuJk1YKQELdIY8uJPY9vZpwZgBeJkrJM0yTQAl0UtBglBZpEgDJexkplPNYU75gcpeNjcXCSnGzAq-5fGF8fYh1wI8lo9DUJOAWkL0j5_NPZIIpTctivoLhzqpw_ehdfyCH4_DIPwyAXWdLWFaJ7POupl63RHxDzMmJtTM7eLfjQvay_afJ5sFzogfnxWx3H__2a23CzxaJs1zPPHdiw1RZc9d0pV1twbdLm3e_Cz93zNnD4zbLpaZQxVZVsOBL94ShO-mjC3vI-oyQAczN_ORs9cHZWESad22a0oT4g5whtGcV-2fd6hgTTMKhhZF6JRXAKG56qj2ruSfWXVU1Nk1f34Hjv9XQ4DtrmDYFBNREiatfOKGuzPFXCCil46PKojHiqXIRcELpScZ4mmbNSa2ldbrLQGm5DZ7g2gm_DZlVX9gEwI5VC1JUbm5Yiim2OIFPGzqAy0k64pAfPu0MsvvoaHUXn2-C2Fs229mCnO96iFdN5EZM-QpAkRQ-erckoYLRhqrL1ksaEVNMNgWIP7nu2WK8SI1_xVCLlZXO4f1--eH-w3zw8_PehT-H6eDo5LA73j948ghv4stLfGdqBzcVsaR8jHFroJw3X_wILXQRc |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRa248CivpQUM4oC0yiqxHccRp2qXVVtoVUEr9YAU2Y5NCyWp9lG03PjnjONk1RYhIW6RxpYTex7fzDgzAK9TJWUpRBppji4KWozSB5p4hDJeUqUyRrWPd-wfiJ1jvneSnqzA2-5fmFAfYhlw85LR6Gsv4BeluyLk069ng4QK76_f4gJRikdEH-mVFEJIL7M4jnKepW1ZIX-NZzn1ujH6A2FeB6yNxRnfhc_du4aLJt8G85kemJ83yjj-58fcgzstEiXbgXXuw4qtNmAt9KZcbMD6fpt1fwC_ts_bsOGlJUenSUZUVZLhiPeHI5r20YAdsj7xKQDiJuFqNvrf5KzyiHRqm9HGdwE5R2BLfOSX_KgnSDANexrijatnEJxChqfqi5oGUv19UfuWyYuHcDx-dzTcidrWDZFBJREjZtfOKGuzXChuueQsdnlSJkwolyAPxK5UjIk0c1ZqLa3LTRZbw2zsDNOGs0ewWtWVfQLESKUQc-XGipIn1OYIMSV1BlWRdtylPXjVnWFxESp0FJ1ng9taNNvag63udItWSKcF9doIIZLkPXi5JKN4-Q1Tla3nfkzsK7ohTOzB48AVy1UoshUTEilvmrP9-_LFp73d5uHpvw99AeuHo3HxYffg_SbcxneV4cLQFqzOJnP7DLHQTD9veP435BEDAg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Alternative+Th17+and+CD4+%2B+CD25+%2B+FoxP3+%2B+cell+frequencies+increase+and+correlate+with+worse+cardiac+function+in+Chagas+cardiomyopathy&rft.jtitle=Scandinavian+journal+of+immunology&rft.au=Almeida%2C+M.+S.&rft.au=Lorena%2C+V.+M.+B.&rft.au=Medeiros%2C+C.+de+A.&rft.au=Junior%2C+W.+O.&rft.date=2018-04-01&rft.issn=0300-9475&rft.eissn=1365-3083&rft.volume=87&rft.issue=4&rft_id=info:doi/10.1111%2Fsji.12650&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_sji_12650 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-9475&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-9475&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-9475&client=summon |