Serum Proteome Profiling of Diabetic Patients Treated With DPP4 and SGLT2 Inhibitors Shows Improved Cognitive and Cardiovascular Functions - Hakim, Md Abdul; Sanni, Akeem; Osman, Shams T.; Hamdy, Noha A.; Purba, Waziha Tasnim; Bhuiyan, Md Mostofa Al Amin; Onigbinde, Sherifdeen; El‐Khordagui, Labiba K.; El‐Yazbi, Ahmed; Mechref, Yehia (Proteomics (Weinheim), 2025)
Keywords: Aged; Alzheimer's disease; Antidiabetics; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Central nervous system; Cognition - drug effects; Cognitive ability; cognitive decline; Combination therapy; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors - pharmacology; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; Drug therapy; Drugs; Female; Glucose; Growth factors; Health services; Humans; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Inhibitors; Insulin; Male; Metabolic disorders; Metformin; Metformin - therapeutic use; Middle Aged; Neurodegenerative diseases; neurovascular coupling; Peptidases; Proteins; Proteome - analysis; Proteome - metabolism; Proteomes; Proteomics; Proteomics - methods; Renal function; Sodium; Sodium-glucose cotransporter; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; Statistical analysis; Synaptogenesis; Type 2 diabetes; Type 2 diabetes; neurovascular coupling; cognitive decline; synaptogenesis