Chondroitin Sulfate as a Key Molecule in the Development of Atherosclerosis and Cancer Progression

• Published in: Advances in Pharmacology Vol. 53; pp. 281 - 295
• Main Authors: Theocharis, A.D., Tsolakis, I., Tzanakakis, G.N., Karamanos, Nikos K.
• Format: Book Chapter Journal Article
• Language: English
• Published: United States Elsevier Inc 2006
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Aorta - physiology; Atherosclerosis - etiology; Biomechanical Phenomena; Chondroitin Sulfate Proteoglycans - chemistry; Chondroitin Sulfate Proteoglycans - physiology; Chondroitin Sulfates - physiology; Chondroitin Sulfates - therapeutic use; Cytokines - physiology; Disease Progression; Epidermal Growth Factor - metabolism; Extracellular Matrix - metabolism; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lipoproteins, LDL - metabolism; Neoplasms - etiology; Signal Transduction; Versicans - physiology

This chapter discusses the molecular involvement of CS in the progression of two main human diseases: cancer and atherosclerosis. Chondroitin sulfate (CS) is a glycosaminoglycan (GAG) composed of repeating disaccharides of glucuronic acid and N‐acetyl‐galactosamine, which are variously substituted b...