Demoxepam Derivatization and GC–MS Analysis Produces Erroneous Nordiazepam and Oxazepam Results

Abstract Demoxepam, when derivatized by silylation and analyzed using gas chromatography-mass spectrometry (GC-MS), produces artifacts which are falsely identified as nordiazepam and oxazepam. Demoxepam was analyzed unextracted at various concentrations, using different derivatization procedures, an...

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Bibliographic Details
Published inJournal of analytical toxicology Vol. 43; no. 5; pp. 406 - 410
Main Authors Sarris, Gregory G, Limoges, Jennifer F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.06.2019
Subjects
Benzodiazepines - analysis
Chlordiazepoxide - analysis
False Positive Reactions
Gas Chromatography-Mass Spectrometry - standards
Humans
Limit of Detection
Nordazepam - analysis
Oxazepam - analysis
Reference Standards
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