Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo‒keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α

• Published in: Biochemical journal Vol. 355; no. 2; pp. 537 - 544
• Main Authors: OZEKI, Takeshi, TAKAHASHI, Yoshiki, KUME, Toshiyuki, NAKAYAMA, Kazuo, YOKOI, Tsuyoshi, NUNOYA, Ken-Ichi, HARA, Akira, KAMATAKI, Tetsuya
• Format: Journal Article
• Language: English
• Published: 15.04.2001
• Subjects: a1-antitrypsin; DD4 gene; dihydrodiol dehydrogenase; HNF-1^a protein; HNF-4^g protein

Human dihydrodiol dehydrogenase (DD) 4/aldo-keto reductase (AKR) 1C4 is a major isoform of hepatic DD that oxidizes trans-dihydrodiols of polycyclic aromatic hydrocarbons to reactive and redox-active o-quinones and that reduces several ketone-containing drugs. To investigate the mechanism of transcr...