A Single Haplotype of IFNG Correlating With Low Circulating Levels of Interferon-γ Is Associated With Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis

• Published in: Clinical infectious diseases Vol. 71; no. 2; pp. 274 - 281
• Main Authors: da Silva, George A V, Mesquita, Tirza G, Souza, Victor C, Junior, José do Espírito Santo, Gomes de Souza, Mara Lúcia, Talhari, Anette Chrusciak, Talhari, Sinésio, Naveca, Felipe G, Ramasawmy, Rajendranath
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 11.07.2020
• Subjects: Animals; Haplotypes; Humans; Interferon-gamma - genetics; Leishmania guyanensis - genetics; Leishmaniasis, Cutaneous - genetics; Mice; Polymorphism, Single Nucleotide; haplotype; Leishmania guyanensis; polymorphisms; interferon-gamma; cutaneous leishmaniasis

Abstract Background Interferon-γ (IFN-γ) plays an important role in the control of Leishmania infection. Blockade of IFN-γ signaling in mice increases lesion size and parasite load. In endemic areas of Leishmaniasis, only a fraction of the population develop the disease. This suggest that host genet...