Genetically engineered stem cells expressing cytosine deaminase and interferon-β migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects

• Published in: International journal of oncology Vol. 39; no. 4; pp. 833 - 839
• Main Authors: YI, Bo-Rim, O, Si-Na, KANG, Nam-Hee, HWANG, Kyung-A, KIM, Seung U, JEUNG, Eui-Bae, KIM, Yun-Bae, HEO, Gang-Joon, CHOI, Kyung-Chul
• Format: Journal Article
• Language: English
• Published: Athens Editorial Academy of the International Journal of Oncology 01.10.2011
• Subjects: Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Cell Communication - physiology; Cell Line, Tumor; Cell Migration Assays - methods; Cell Movement - physiology; Chemotactic Factors - metabolism; Cytosine Deaminase - biosynthesis; Cytosine Deaminase - genetics; Drug Delivery Systems - methods; Flucytosine - administration & dosage; Flucytosine - pharmacokinetics; Fluorouracil - pharmacokinetics; Fluorouracil - pharmacology; Genetic Engineering - methods; Genetic Therapy - methods; Humans; Interferon-beta - biosynthesis; Interferon-beta - genetics; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Medical sciences; Pneumology; Prodrugs - pharmacokinetics; Prodrugs - pharmacology; Stem Cells - cytology; Stem Cells - metabolism; Stem Cells - physiology; Tumors; Tumors of the respiratory system and mediastinum; Human; Tropism; Lung disease; tumor tropism; Enzyme; Respiratory disease; Cytosine deaminase; interferon-β; Lung cancer; Stem cell; Cytokine; Malignant tumor; therapeutic stem cells; Cancerology; Treatment; Beta interferon; Hydrolases; Bronchus disease; Genetics; Tumor cell; Cancer

Recent studies have shown that genetically engineered stem cells (GESTECs) produce suicide enzymes that convert non-toxic pro-drugs to toxic metabolites which selectively migrate toward tumor sites and reduce tumor growth. In the present study, we evaluated whether these GESTECs are capable of migra...