Beneficial Effects of the Herbal Medicine Di Huang Yin Zi in Patients with Spinal Cord Injury: A Randomized, Placebo-controlled Clinical Study

Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI). Methods: In this doubleblind, placebo-controlled study, patients with traumatic SCI and American Spinal...

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Published inJournal of international medical research Vol. 40; no. 5; pp. 1715 - 1724
Main Authors Li, YL, Li, LT, Yu, M, Wang, YZ, Ge, HY, Song, CQ
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.10.2012
Subjects
Adult
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Male
Medicine, Chinese Traditional
Middle Aged
Nerve Regeneration - drug effects
Paraplegia - drug therapy
Paraplegia - physiopathology
Recovery of Function - drug effects
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - physiopathology
Complementary medicine
Chinese medicine
Functional recovery
Di Huang Yin Zi (DHYZ)
Spinal cord injury
Alternative medicine
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Abstract Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI). Methods: In this doubleblind, placebo-controlled study, patients with traumatic SCI and American Spinal Injury Association (ASIA) impairment grades B - D were randomized to receive DHYZ (n = 30) or placebo (n = 30) for 12 weeks. Both groups also received rehabilitation therapy during the study period. Motor and sensory function and activities of daily living (ADL) were assessed before treatment and at 4-week intervals. Results: Significantly more patients in the DHYZ group showed an improved ASIA impairment grade during the treatment period (32.1%) compared with the placebo group (10.3%), and scores for sensory and motor function and ADL at the end of the treatment period were significantly higher in the DHYZ group than in the placebo group. No serious side-effects were reported. Conclusions: DHYZ was found to improve neurological function in patients with SCI and may be an effective adjuvant therapy to enhance functional recovery.
AbstractList This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI). In this double-blind, placebo-controlled study, patients with traumatic SCI and American Spinal Injury Association (ASIA) impairment grades B-D were randomized to receive DHYZ (n = 30) or placebo (n = 30) for 12 weeks. Both groups also received rehabilitation therapy during the study period. Motor and sensory function and activities of daily living (ADL) were assessed before treatment and at 4-week intervals. Significantly more patients in the DHYZ group showed an improved ASIA impairment grade during the treatment period (32.1%) compared with the placebo group (10.3%), and scores for sensory and motor function and ADL at the end of the treatment period were significantly higher in the DHYZ group than in the placebo group. No serious side-effects were reported. DHYZ was found to improve neurological function in patients with SCI and may be an effective adjuvant therapy to enhance functional recovery.
Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI). Methods: In this doubleblind, placebo-controlled study, patients with traumatic SCI and American Spinal Injury Association (ASIA) impairment grades B - D were randomized to receive DHYZ (n = 30) or placebo (n = 30) for 12 weeks. Both groups also received rehabilitation therapy during the study period. Motor and sensory function and activities of daily living (ADL) were assessed before treatment and at 4-week intervals. Results: Significantly more patients in the DHYZ group showed an improved ASIA impairment grade during the treatment period (32.1%) compared with the placebo group (10.3%), and scores for sensory and motor function and ADL at the end of the treatment period were significantly higher in the DHYZ group than in the placebo group. No serious side-effects were reported. Conclusions: DHYZ was found to improve neurological function in patients with SCI and may be an effective adjuvant therapy to enhance functional recovery.
Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI). Methods: In this doubleblind, placebo-controlled study, patients with traumatic SCI and American Spinal Injury Association (ASIA) impairment grades B - D were randomized to receive DHYZ ( n = 30) or placebo ( n = 30) for 12 weeks. Both groups also received rehabilitation therapy during the study period. Motor and sensory function and activities of daily living (ADL) were assessed before treatment and at 4-week intervals. Results: Significantly more patients in the DHYZ group showed an improved ASIA impairment grade during the treatment period (32.1%) compared with the placebo group (10.3%), and scores for sensory and motor function and ADL at the end of the treatment period were significantly higher in the DHYZ group than in the placebo group. No serious side-effects were reported. Conclusions: DHYZ was found to improve neurological function in patients with SCI and may be an effective adjuvant therapy to enhance functional recovery.
OBJECTIVEThis study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in spinal cord injury (SCI).METHODSIn this double-blind, placebo-controlled study, patients with traumatic SCI and American Spinal Injury Association (ASIA) impairment grades B-D were randomized to receive DHYZ (n = 30) or placebo (n = 30) for 12 weeks. Both groups also received rehabilitation therapy during the study period. Motor and sensory function and activities of daily living (ADL) were assessed before treatment and at 4-week intervals.RESULTSSignificantly more patients in the DHYZ group showed an improved ASIA impairment grade during the treatment period (32.1%) compared with the placebo group (10.3%), and scores for sensory and motor function and ADL at the end of the treatment period were significantly higher in the DHYZ group than in the placebo group. No serious side-effects were reported.CONCLUSIONSDHYZ was found to improve neurological function in patients with SCI and may be an effective adjuvant therapy to enhance functional recovery.
Author Li, YL
Ge, HY
Yu, M
Li, LT
Song, CQ
Wang, YZ
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Keywords Complementary medicine
Chinese medicine
Functional recovery
Di Huang Yin Zi (DHYZ)
Spinal cord injury
Alternative medicine
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Snippet Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological...
This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological disorders, in...
Objective: This study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological...
OBJECTIVEThis study investigated the safety and therapeutic efficacy of Di Huang Yin Zi (DHYZ), a traditional Chinese decoction used to treat neurological...
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crossref
pubmed
sage
SourceType Aggregation Database
Index Database
Publisher
StartPage 1715
SubjectTerms Adult
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Male
Medicine, Chinese Traditional
Middle Aged
Nerve Regeneration - drug effects
Paraplegia - drug therapy
Paraplegia - physiopathology
Recovery of Function - drug effects
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - physiopathology
Title Beneficial Effects of the Herbal Medicine Di Huang Yin Zi in Patients with Spinal Cord Injury: A Randomized, Placebo-controlled Clinical Study
URI https://journals.sagepub.com/doi/full/10.1177/030006051204000510
https://www.ncbi.nlm.nih.gov/pubmed/23206453
https://search.proquest.com/docview/1222235704
Volume 40
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