Lung epithelial cell apoptosis during acute lung injury in infancy

Apoptosis of lung epithelial cells is implicated in the pathogenesis of acute lung injury. Most research on this subject has focused on adults. Very little is known about a potential interaction of this process with lung development in children. To summarize the current literature on lung epithelial...

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Published inPediatric critical care medicine Vol. 8; no. 2; p. 132
Main Authors Bem, Reinout A, Bos, Albert P, Matute-Bello, Gustavo, van Tuyl, Minke, van Woensel, Job B M
Format Journal Article
LanguageEnglish
Published United States 01.03.2007
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Abstract Apoptosis of lung epithelial cells is implicated in the pathogenesis of acute lung injury. Most research on this subject has focused on adults. Very little is known about a potential interaction of this process with lung development in children. To summarize the current literature on lung epithelial cell apoptosis and common causes of acute lung injury in infants and young children and to identify new areas of research. A Medline-based literature search. Few studies have focused on lung epithelial cell apoptosis during common causes of acute lung injury in children. Nevertheless, the limited literature suggests that this may be an important mechanism during respiratory distress syndrome of infants and viral respiratory tract infection. Apoptosis is an essential process during lung development and maturation. Insufficient attention has been paid to potential consequences of this for the short- and long-term outcomes of acute lung injury.
AbstractList Apoptosis of lung epithelial cells is implicated in the pathogenesis of acute lung injury. Most research on this subject has focused on adults. Very little is known about a potential interaction of this process with lung development in children. To summarize the current literature on lung epithelial cell apoptosis and common causes of acute lung injury in infants and young children and to identify new areas of research. A Medline-based literature search. Few studies have focused on lung epithelial cell apoptosis during common causes of acute lung injury in children. Nevertheless, the limited literature suggests that this may be an important mechanism during respiratory distress syndrome of infants and viral respiratory tract infection. Apoptosis is an essential process during lung development and maturation. Insufficient attention has been paid to potential consequences of this for the short- and long-term outcomes of acute lung injury.
Author Bem, Reinout A
van Woensel, Job B M
van Tuyl, Minke
Matute-Bello, Gustavo
Bos, Albert P
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References 17622931 - Pediatr Crit Care Med. 2007 Jul;8(4):410; author reply 410
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Snippet Apoptosis of lung epithelial cells is implicated in the pathogenesis of acute lung injury. Most research on this subject has focused on adults. Very little is...
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StartPage 132
SubjectTerms Acute Disease
Apoptosis - physiology
Child
Child, Preschool
Epithelial Cells - pathology
Humans
Infant
Infant, Newborn
Lung - cytology
Lung - pathology
Respiratory Distress Syndrome, Adult - pathology
Respiratory Distress Syndrome, Newborn - pathology
Title Lung epithelial cell apoptosis during acute lung injury in infancy
URI https://www.ncbi.nlm.nih.gov/pubmed/17273113
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