Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects

• Published in: Molecular psychiatry Vol. 4; no. 5; pp. 476 - 483
• Main Authors: Gelernter, J, Kranzler, H, Cubells, J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.1999; Nature Publishing Group
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcoholism - ethnology; Alcoholism - genetics; Alleles; Amino acid sequence; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain Chemistry - genetics; Cocaine-Related Disorders - ethnology; Cocaine-Related Disorders - genetics; Drug addiction; Drug dependence; Exons - genetics; Female; Gene Frequency; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Narcotics; Neurosciences; Opioid receptors; Opioid-Related Disorders - ethnology; Opioid-Related Disorders - genetics; original-research-article; Pharmacotherapy; Polymerase Chain Reaction; Polymorphism, Genetic; Population genetics; Population studies; Population-based studies; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Opioid, mu - genetics; Restriction fragment length polymorphism; Risk factors; μ opioid receptor; association; genetic polymorphism; linkage disequilibrium; substance dependence; Human; Drug addiction; Illicit drug; Pathogenesis; Alcoholism; μ Opioid receptor; Genetic determinism; Alcoholic beverage; Gene; Dependence; Risk factor; Genetics; Polymorphism

The gene encoding the μ opioid receptor, OPRM1, contains at least two polymorphisms affecting protein sequence in exon 1, Ala6Val and Asp40Asn. In previous studies, each variant has been reported to be associated with some form of drug dependence. Although past reports have not been consistent, they...