Chitosan-P407-PNIPAM hydrogel loaded with AgNPs/lipid complex for antibacterial, inflammation regulation and alveolar bone regeneration in periodontitis treatment

• Published in: International journal of biological macromolecules Vol. 307; no. Pt 4; p. 142080
• Main Authors: Zhang, Chengdong, Fei, Yachen, Li, Meng, Li, Jing, Tang, Maomao, Wang, Guichun, Li, Jiaxin, Wang, Yuxiao, Ding, Yang, Peng, Chengjun, Li, Mengjie, Gui, Shuangying, Guo, Jian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2025
• Subjects: Acrylic Resins - chemistry; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial; Bone Regeneration - drug effects; Chitosan - chemistry; Humans; Hydrogels - chemistry; Inflammation - drug therapy; Inflammation regulation; Lipids - chemistry; Metal Nanoparticles - chemistry; Mice; Osteogenesis; Periodontitis; Periodontitis - drug therapy; Periodontitis - pathology; Porphyromonas gingivalis - drug effects; Smart hydrogel; Antibacterial; Periodontitis; Smart hydrogel; Inflammation regulation; Osteogenesis

Periodontitis is an oral chronic inflammatory disease induced by pathogenic bacteria. Pathogens continuously activate immune cells to express a large number of pro-inflammatory factors and reactive oxygen species, eventually leading to periodontal tissue damage. Poor eradication of pathogenic bacter...