Nefazodone pharmacokinetics: assessment of nonlinearity, intra-subject variability and time to attain steady-state plasma concentrations after dose escalation and de-escalation

• Published in: European journal of clinical pharmacology Vol. 50; no. 1-2; p. 101
• Main Authors: Barbhaiya, R H, Shukla, U A, Chaikin, P, Greene, D S, Marathe, P H
• Format: Journal Article
• Language: English
• Published: Germany 1996
• Subjects: Adult; Antidepressive Agents, Second-Generation - administration & dosage; Antidepressive Agents, Second-Generation - blood; Antidepressive Agents, Second-Generation - pharmacokinetics; Biotransformation; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Male; Piperazines; Spectrophotometry, Ultraviolet; Triazoles - administration & dosage; Triazoles - blood; Triazoles - pharmacokinetics

The time required to reach steady-state plasma levels after an increase and a subsequent decrease in the dose of nefazodone, an antidepressant drug with nonlinear pharmacokinetics, was assessed in 24 healthy, male volunteers. Each subject was administered 100 mg nefazodone hydrochloride b.i.d. (q 12...