Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes

• Published in: The Journal of cell biology Vol. 121; no. 5; pp. 1141 - 1152
• Main Authors: Wayner, E A, Gil, S G, Murphy, G F, Wilke, M S, Carter, W G
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 01.06.1993
• Subjects: Basement Membrane - chemistry; Cell Adhesion; Cell Adhesion Molecules - metabolism; Cells, Cultured; Endothelium, Vascular - cytology; Epithelium - chemistry; Extracellular Matrix - chemistry; Graft vs Host Reaction - immunology; Humans; In Vitro Techniques; Integrins - metabolism; Kalinin; Ligands; T-Lymphocyte Subsets - cytology; Up-Regulation

The cutaneous T cell lymphomas (CTCL), typified by mycosis fungoides, and several chronic T cell mediated dermatoses are characterized by the migration of T lymphocytes into the epidermis (epidermotropism). Alternatively, other types of cutaneous inflammation (malignant cutaneous B cell lymphoma, CB...